Introduction to Autonomic Pharmacology Flashcards
Name some ANS NT
Acetylcholine and norepinephrine
Sympathetic and parasympathetic messengers
Sympathetic - preganglionic releases ACh…binds nicotinic…release NE…binds adrenergic
Parasympathetic - preganglion releases Ach…binds nicotinic…releases Ach….binds muscarinic
Symp and parasymp organization
Sym - thoracolumbar with short - ganglion - long
Parasymp - craniosacral with long - ganglion short
Both SNS and PNS are connected to CNS via the
hypothalamus which receives connections from limbic structures
Dorsal longitudinal fasculus
Midbrain, pons, and medulla
ANS not only composed of efferents
Reflexes
Baroreceptors reflex, carotid bodies, chemoreceptors, and stretch receptors (micturition)
Medullary cardiovascular center
Nucleus tractus solitarius (vasomotor area)…baroreceptors from carotid sinus and aortic arch stretch
Parasympathetic nervous system carries
Dominant tone at rest while sympathetic carries fight or flight
Divergence of symp and parasymp
Symp - diffuse output
Parasymp - discrete because only one organ
Cholinergic transmission
Action potential…presynaptic depolarization…Ca entry…vesicle fusion…NT release
M1 receptor
Nerves, enteric ganglia
GPCR
Uses IP3 and DAG
M2 receptor
Heart, nerves, smooth muslce
GPCR
Inhibition of cAMP, K= channel activaiton
M3 receptor
Glands, smooth muscle, patietal, endothelium
GPCR
IP3 and DAG cascade
Nm receptor
Skelatal muscle NMJ
Na+, Ca depolarizing ion channel
Nn
Postganglionic cell body
Na, Ca depolarizing ion channel
