Introduction to ANS Pharmacology and CIS cases -Kruse

Question 1

what sympathetic nerve uses Ach for postsynaptic nerve and what kind to receptor does it have

Answer 1

Sweat glands

mAchR

Question 2

M1
M3
M5 receptors

Answer 2

M1 : CNS
M3 : Glands, SM, endothelium (vasculature when NO binds), (lungs)
M5 : CNS
= all activate

Question 3

M2

M4 receptors

Answer 3

M2 : heart, lungs, nerves, SM (inhibit)
M4 : CNS
= all inhibitory

Question 4

Nm

Nn receptors

Answer 4

Nm : skeletal muscles neuromuscular junctions

Nn : Postganglionic cell body from pre-gang, dendrites, CNS

Question 5

synthesis of Epi and NE

Answer 5

Tyrosine —-> L-DOPA—-> Dopamine—-> NE —-> E

Question 6

synthesis of Epi and NE what happens in the cytoplasm

Answer 6

Tyrosine –> L-Dopa –> dopamine (leaves cytoplasm and enters vesicle)

Question 7

synthesis of Epi and NE what happens in the vesicle

Answer 7

Dopamine –> NE–> E (leaves vesicle)

Question 8

synthesis of Epi and NE what happens in the adrenal medulla

Answer 8

NE –> E

Question 9

Na+ dependent tyrosine transporter

Answer 9

transport tyrosine to nerve

Question 10

VMAT-2

Answer 10

transports NE, Epi, DA, serotonin into vesicles

* contents released like Epi when Ca+2 influx and AP occurs

Question 11

NE transporter (NET)
DAT

Answer 11

import NE back into nerve vesicles after released

imports DA back into nerve vesicles after released

Question 12

what breaks down NE and Api

Answer 12

has to be done inside the nerve
MAO
COMT

Question 13

a1 receptors

Answer 13

a1 : vasculature, heart, GI (relaxation)
= all increase
= use Epi most

Question 14

a2 receptors

Answer 14

a2 : insulin from B-cells (decrease), Vasculature SM (contraction), platelet aggregation
= inhibitory
= uses Epi more

Question 15

B1
B2
B3 receptors

Answer 15

B1 : Juxta cells, HEART (increase renin + HR)
B2 : SM vasculature(RELAX), LUNG RELEAX
B3 : Adipose tissue (lipolysis)
= all are excitatory 
= B1 + B2 use Epi, B3 use NE

Question 16

vasodilation is done by

Answer 16

E + NE—-> B2

NO—-> M3

Question 17

vasoconstriction is done by

Answer 17

E + NE —-> a1

Question 18

NO goes to what part of vasculature

Answer 18

binds to SM which has the receptors for it

= no parasympathetic nerves here

Question 19

what makes what release NO

Answer 19

ACH binding to M3 receptors on the vasculature endothelial cells make them release NO

Question 20

what makes adrenal medulla release Epi and NE

Answer 20

Ach binds to NnAchR
80% E
20% NE

Question 21

how do baroreceptors act when high BP, or having phenylephrine

Answer 21

lower para and increase sympa

Question 22

how do baroreceptors act when low BP, or having Histamine

Answer 22

increase parasympathetic

decrease sympathetic