INTRODUCTION

Question 1

WHAT IS DEV NEUROBIOLOGY

Answer 1

THE STUDY OF HOW THE NS AND ITS RESIDENT CELL TYPES FORM

Question 2

WHAT OCCURS IN DEVELOPMENT

Answer 2

1. CELL DIVISION
2. AXIS FORMATION
3. CELL DIFFERENTIATION
4. MORPHOGENESIS

ALL SIMULTANEOUSLY OVER TIME

Question 3

WHAT GUIDES CELL BEHAVIOUR

Answer 3

1. EXTRINSIC SIGNALS

2. INTRINSIC SIGNALS

Question 4

WHERE DO AUTONOMOUS SIGNALS COME FROM

Answer 4

THEY ARE INHERITED LINEAGE AT THE POINT OF CELL DIVISION

Question 5

WHERE DO EXTRINSIC SIGNALS COME FROM

Answer 5

CHEMICAL SIGNALS FROM NEIGHBOURING CELLS

Question 6

EVERY CELL CARRIES 20,000 GENES - WHY ARE THEY DIFFERENT AND WHAT THEORIES ARE THERE

Answer 6

1. OLD THEORY - DNA IS CHUCKED OUT
2. OLD THEORY - ASYMMETRIC DISTRIBUTION OF FATE DETERMINING MOLECULES
3. DIFFERENTIAL GENE EXPRESSION - IN EACH CELL AT ANY POINT IN TIME, ONLY A SUBSET OF GENES IS TRANSCRIBED

Question 7

WHAT IS AN ENHANCER

Answer 7

SHORT REGIONS OF DNA THAT ACTS ON THE SAME GENE BUT FURTHER AWAY

Question 8

WHAT IS THE ROLE OF AN ENHANCER

Answer 8

ACTIVATORS/INHIBITORS BIND TO ENHANCERS TO FORM A COMPLEX. THIS LOOPS THE DNA ROUND TO FIT ON THE CO-ACTIVATOR OF THE PROMTOER REGIONS WITH RNA POLYMERASE AND CONTROLS THE TRANSCRIPT RATE

Question 9

OVER TIME, WHAT CAN BE SAID ABOUT SPECIALISATION AND PLURIPOTENCY

Answer 9

SPECIALISATION INCREASES

PLURIPOTENCY DECREASES