intro to medical immunology Flashcards
What are the 4 types of pathogens?
Extracellular bacteria, intracellular bacteria , viruses , parasites, parasitic worms
Where are the majority of leukocytes from?
HSCs- Hematopoeitic stem cells
What determines the differentiation of leukocytes?
Their microenviroment
What does philia and penia mean?
Too many cells , too few cells
How many lobes does a neutrophil have
2-5 lobes
Main function of neutrophils
Phagocytosis , releasing antimicrobial species , granule release
WHat is the role of neutrophils in infections
They are the first defenders at the site of bacterial infection.
what are the 3 stages of inflammation
initiation , recruitment of effector cells and resolutions
main types of t cells and their functions
CD8- destroy virus infected or cancer cells
CD4- provide help to b cells
What do b cells turn into and what does this provide
Mature into plasma cells that produce antibodies , providing humoral immunity
funtion of nk cells
lyse virus infected host cells and tumours
What are esoinophils involved in
allergic reactions and parasitic infections , they are bi lobed
What are mast cells and basophils
involved in inflammation and allergic response
contains histamine and heparin
ige receptors present
Monocytes and macrophages
Monocytes are involved in circulating tissue macrophages in inflammation
Macrophages , phagocyotise , kill bacteria and are involves in antigen uptake and presentation
