Inflammasome Flashcards
What is the role of PRR in immune detection
They detect and recognise pamps and damps triggering inflammation through cytokines
What is the function of IL-1B
center mediator of innate immunity and inflammation
IL1B regulaion is regulated by
receptor antagonist
soluble and decoy receptors
Negative regulation of receptor binding
What are the 2 stages of inflammasome activation
Priming stage:induced by PAMPsor DAMPS and causes upregualtion of inflammasome components
Activation stage:requires a second signal for inflammasome assembly
What are the key domains involved in inflammasome activation
PYD,CARD,NACHT domain
What is pyropoptosis and how is it triggered?
Form of cell death triggered by caspase 1 activation which cleaves pro il1b and proil-18 into active cytokines leading to gasdermin d pore formation in the membrane
What are the triggers of inflammasome activation
reactive oxygen species
mitochondrial dna release
k+efflux
Lysosomal damage
NINJ1
What is CAPS
it is a syndrome caused by inflammasome hyperactivation leading to antiinflammatory responses
How does gout involve inflammasomes
Uric acid crystals trigger NLRP3 inflammasome activation leading to inflammation
How does athlerosclerosis ans silicosis involve inflammasomes?
Athlerosclerosis -cholesterol crystals activate NLRP3 contributing to plaque formation
ASBESTOSI - triggered by inhaled crystalline particles
What is DIRA
Causes sterile osteomyelitis ,periostitis , pustosis
What role does il36 play in disease
Plays a role in generalised pustular psoraisis and defiency of DITRA which the then leads to severe inflammation.
How doe pathogens evade inflammasome activation
Kaposis sarcome produces NLRP1 homolog to interfere with host inflammasomes
Pox viruses produce M1£L to block inflammasome activation.
What is the role of inflammasomes
They regulate IL1b and IL18 in inflammation . Dysregulation leads to disease.
