Autoinflammatory Disease

Question 1

What distinguishes autoinflammatory disease from autoimmune disease

Answer 1

Lack of high titre autoantibodies ,antigen specific t cells and auto antigenic exposure

Question 2

What are autoinflammatory disease

Answer 2

A group of inherited disorders causing spontaneous systemic inflammation without an autoimmune basis

Question 3

Name 3 autosomal dominant auntoinflammatory diseases

Answer 3

TRAPS (TNF- receptor -associated- periodic-syndrome ). Muckle- Wells syndrome,PAPA syndrome

Question 4

Name 2 autosomal recessive autoinflammatory diseases

Answer 4

Familial Mediterrean Fever(FMF),Hyper IgD syndrome(HIDS)

Question 5

Name 3 key IL-1 family cytokines involved in antiinflammatory disease

Answer 5

IL-1B ,IL-36,IL-18

Question 6

What are the symptoms of DIRA

Answer 6

Sterile multifocal osteomyelitis ,periostitis ,pustulosis

Question 7

What is the treatment for DIRA

Answer 7

IL-1 recpetor antagonists (e.g Anakinra )

Question 8

What IL-1 inhibitor is used for resistant gout

Answer 8

Anakinra

Question 9

How does IL-36 contribute to psoriasis

Answer 9

IL36y is highly upregulated in psoriatic lesions ,increasing inflammation

Question 10

Name 2 polygenic autoinflammatory disease

Answer 10

Crohns disease ,Gout

Question 11

Name 2 disease that overlap between innate and adaptive immunity

Answer 11

Ankylosing spondilytis ,Reactive arthiritis

Question 12

What is a common treatment approach for antiinflammatory disease

Answer 12

Anti-cytokine therapy (e.g IL-1 ,TNF inhibitors )