Extracellular immunity 2 Flashcards
what types of pathogens are spread by mosquitos
Viruses
Parasites
what are factors speading mosquito borne disease
Globalisation
Climate change
How are arboviruses transmitted
They require high blood levels to infect mosquitos spreading the virus
Disease caused by arboviruses
DENGUE<ZIKA<YELLOW FEVER
BLUETONGUE -equine encephalitus
What are the challenges in arbovirus outbreaks
no licensed antivirals and few vaccines
What happens to the immune system during a mosquito bite
triggers a inflammtory response and immune cell recruitment
can help viruses establish an infection before adaptive immunity
What is the role of innate immunity in responding to mosquitos borne pathogens
PRRs detect viral rna/dna
type 1 IFNs limit viral replication
How do viruses evade innate immunity
Counteracting IFN signalling
What is the role of CD8+ cells and Igg in defending against antibodies
CD8 t cells kill infected cells
igg antibodies neutralize the viruses
what is the issue with dengue immunity in secondary infection
ADE occurs where igg antibodies from previous serotype infection worsen disease when facing that with a different serotype.
How does malaria evade the immune system
Innate immunity is limited due to the intracellular nature of the parasite
the parasite changes it surface antigens to evade recognition by the immune system
What type of adaptive immunity is important in malaria
TH1 , CD* and igg
