Internal Med Hematology

Question 1

s/s of leukemia

Answer 1

• fever
• anemia
• lymphadenopathy
• bone pain

Question 2

diagnosis of ALL

Answer 2

• bone marrow biopsy
• lymphoblasts

Question 3

treatment of ALL

Answer 3

• induction chemo and CNS prophylaxis
• post-remission therapy

Question 4

diagnosis of CLL

Answer 4

• lymphocytes
• smudge cells

Question 5

treatment of CLL

Answer 5

multidrug chemo

Question 6

diagnosis of AML

Answer 6

• auer rods
• myeloblasts

Question 7

treatment of AML

Answer 7

multidrug chemo and postremission chemo

Question 8

diagnosis of CML

Answer 8

• philadelphia chromosome
• myelocytes

Question 9

treatment of CML

Answer 9

TK inhibitors

Question 10

S/S of Anemia of chronic disease

Answer 10

fatigue, weakness, DOE, anorexia

Question 11

treatment of anemia of chronic disease

Answer 11

• treat underlying cause
• EPO
• transfusions

Question 12

etiology of G6PD deficiency

Answer 12

x-linked recessive

Question 13

S/S of G6PD Deficiency

Answer 13

• heinz bodies
• jaundice
• triggers (fava beans, asa, abx, and azo)
• dark urine
• abd or lumbar pain

Question 14

Treatment of G6PD deficiency

Answer 14

• avoid triggers
• folic acid supplementation

Question 15

s/s of ITP

Answer 15

• generally healthy kid
• petechiae
• purpura
• ecchymoses
• mucosal bleeding

Question 16

diagnosis of ITP

Answer 16

isolated thrombocytopenia

Question 17

treatment of ITP

Answer 17

• watchful waiting at first
• severe: steroids

Question 18

etiology of iron deficiency anemia

Answer 18

• deficient intake
• chronic blood loss
• decreased absorption

Question 19

s/s of iron deficiency anemia

Answer 19

• pallor
• fatigue
• pica
• brittle nails

Question 20

treatment of iron deficiency anemia

Answer 20

iron replacement

Question 21

presentation of non-hodgkin lymphoma

Answer 21

• painless lymphadenopathy
• constitutional symptoms

Question 22

diagnosis of non-hodgkin lymphoma

Answer 22

lymph node biopsy

Question 23

treatment of non-hodgkin lymphoma

Answer 23

single or multidrug chemo

Question 24

presentation of hodgkin lymphoma

Answer 24

• painless lymph mass
• reed sternberg cells
• constitutional symptoms

Question 25

treatment of hodgkin lymphoma

Answer 25

multidrug chemo

Question 26

presentation of multiple myeloma

Answer 26

* bone pain * pathologic fractures * plasmacytomas

Question 27

diagnosis of multiple myeloma

Answer 27

* RBC rouleaux * lytic bone lesions

Question 28

management of multiple myeloma

Answer 28

* induction chemo * stem cell transplant * radiation

Question 29

etiology of sickle cell anemia

Answer 29

autosomal recessive

Question 31

diagnosis of sickle cell

Answer 31

* sickle cells * howell jolly bodies * HbF

Question 32

treatment of sickle cell anemia

Answer 32

* folic acid supplementation * hydroxyurea * hydration, oxygen, pain control * definitive: stem cell transplant

Question 33

etiology of alpha thalassemia

Answer 33

gene deletions leading to reduced alpha chain synthesis

Question 34

s/s of alpha thalassemia

Answer 34

* target cells * inclusion bodies

Question 35

Treatment of alpha thalassemia

Answer 35

* trait: none * hemoglobin H: folic acid * hydrops fetalis: typically lethal in womb

Question 36

s/s of beta thalassemia

Answer 36

* chipmunk face * target cells * thin long bones * pathologic fractures

Question 37

treatment of beta thalassemia

Answer 37

bone marrow transplant

Question 38

etiology of TTP

Answer 38

adamts13

Question 39

s/s of TTP

Answer 39

* AMS * fatigue * petechiae * fever * dark urine

Question 40

diagnosis of TTP

Answer 40

* schistocytes * negative coombs test

Question 41

treatment of TTP

Answer 41

plasma exchange with FFP

Question 42

presentation of B12 deficiency

Answer 42

* anemia * fatigue * neuropathy * glossitis * angular cheilosis

Question 43

diagnosis of B12 deficiency

Answer 43

* increased methymalonic acid * increased homocysteine

Question 44

treatment of B12 deficiency

Answer 44

replacement

Question 45

s/s of folic acid deficiency

Answer 45

* anemia * glossitis * fatigue * anglar cheilosis * NO neuropathy

Question 46

treatment of folic acid deficiency

Answer 46

replacement