Interleukins Flashcards
Which cytokines are pro-inflammatory?
IL-1
IL-6
TNF alpha
MOA of IL-6?
Secreted by Th cells and macrophages.
Stimulates the production of acute phase reactants and Ig.
Pro-inflammatory cytokine.
TGF - B1 MOA?
Essential cytokine in the mediation of immune response tolerance to commensal bacteria in the gut.
Released by T reg cells and inhibit actions of other T cells and down regulates inflammatory response.
IL-4. MOA?
Secreted by TH2 cells.
Promotes growth of B cells.
Enhances class switching to IgE and IgG.
Overproduction of IL- 4 is associated with allergies.
IL 4 stimulates activated B cell and T cell proliferation
IL- 4 decreases the production of TH1 cells, macrophages, IFN-gamma and dendritic cell IL-12
IL-10. MOA?
Secreted by T reg cells.
Inhibits actions of activated T cells.
AKA human cytokine synthesis inhibitor factor
IL -1
Secreted by
MOA
Secreted by macrophages.
Causes acute inflammation.
Induces chemokine production to recruit leucocytes, activates endothelium to express adhesion molecules.
IL-2
Secreted by
MOA
Secreted by Th cells.
Stimulates growth of helper and cytotoxic T cells.
IL-3
Secreted by
MOA
Secreted by activated T cells.
Supports the growth and differentiation of bone marrow stem cells.
Has a function similiar to MG-CSF
IL-5
Secreted by TH2 cell.eosinophils
Promotes differentiation of B cells.
Enhances class switching to IgA.
Stimulates production and activation of neutrophils.
IL-8
Secreted by macrophages.
Major chemotactic factor for neutrophils.
“Clean up aisle 8” - neutrophils clear infections
IL-12
Secreted by B cells and macrophages.
Activates NK cells and Th1 cells.
y-interferon
Secreted by TH1 cells.
Stimulates macrophages.
TNF
Secreted by macrophages.
Mediates septic shock.
Causes leucocyte recruitment, vascular leak.
