Hepatitis C Tx Flashcards
1
Q
Interferon. MOA.
AE.
A
Antoviral Immunomodulatory Monotherapy low efficiacy Pegylated - long acting No drug resistance
AE: Flu like illness Neuropyschiatric Insomnia Leucopenia and thrombocytopenia Weight loss Hair loss Less common - thyroid dysfunction and induction AI disease
2
Q
Ribavarin. MOA. AE.
A
Synthetic guanosine analogue
Broad spectrum antiviral
MOA:
Antiviral
Enhances immune response
Ineffective as monotherapy
AE:
Haemolytic anaemia
Teratogenicity
Others: rash, pruritis, cough, dyspnea, GI
3
Q
What are the Tx CI?
A
Significant psychiatric illness Non compliance Alcohol intake > 7 SD/week Pregnancy/lactation Decompensated cirrhosis Unable to tolerate low Hb Solid organ tranplant
4
Q
Factors predictive of response to Tx?
A
RVR - HCV RNA neg wk 4 IL28B CC Genotype 2/3 Low viral load No fibrosis/cirrhosis Female Age
5
Q
Direct antiviral agents. Examples. AE?
A
Telepravir
- rash, anorectal discomfort
Bocepravir - anaemia, dysgeusia
Better outcomes however increased rates discontinuation due to AE
6
Q
Sofosbuvir?
A
Nucleotide inhibitor of HCV ploymerase
