Innate Immunity- Non Specific Defense

Question 1

are you born with innate immunity or is it developed

Answer 1

born with it

Question 2

what kind of response does the non specific defense create

Answer 2

generic response- not specific to antigens

Question 3

does innate immunity recognize antigens specifically

Answer 3

no, it has no specific recognition of antigens

Question 4

the first line of the non specific defenses includes what

Answer 4

skin and mucus membranes

Question 5

the second line of the non specific defenses includes what

Answer 5

1. phagocytes and antigen presenting cells
2. natural killer cells
3. interferons
4. inflammation
5. fever
6. interleukins

Question 6

phagocytes and antigen presenting cells:

1. destroy an ____ in lysosome and present fragments on surface
2. attracts ____ cells to begin acquired immune response

Answer 6

phagocytes and antigen presenting cells:

1. destroy an ANTIGEN in lysosome and present fragments on surface
2. attracts HELPER T cells to begin acquired immune response

Question 7

natural killer cells:

1. bind to a target cell + via ______ releases perforin which bind to target cells membrane + perforates it
2. target cell may be ______ or ______ infected cell
3. releases ________

Answer 7

natural killer cells:

1. bind to a target cell + via EXOCYTOSIS releases perforin which bind to target cells membrane + perforates it
2. target cell may be FOREIGN or VIRUS infected cell
3. releases INTERFERONS

Question 8

interferons:
1. secreted by _____ or NK cells
2. coats and _____ neighboring cells membranes

Answer 8

interferons:
1. secreted by VIRUS INFECTED CELLS or NK cells
2. coats and PROTECTS neighboring cells membranes

Question 9

inflammation:
4 signs: ___ ____ ____ ____
1. injured/infected cells produce ______ and _______
2. ______ causes vasodilation and capillaries become leaky
3. vasodilation increases blood flow (O2, WBCs, Glucose)
increases _____ to promote healing
4. localized edema
a. _____ joint
b. dilute and flush ______
5. chemotaxis
a. infected/injured cells release ______
b. attracts ____ into the tissue

Answer 9

inflammation:
4 signs: HEAT,SWELLING, REDNESS, PAIN
1. injured/infected cells produce CYTOKINES and HISTAMINE
2. HISTAMINE causes vasodilation and capillaries become leaky
3. vasodilation increases blood flow (O2, WBCs, Glucose)
increases METABOLISM to promote healing
4. localized edema
a. STABALIZE joint
b. dilute and flush INFECTIOUS AGENTS
5. chemotaxis
a. infected/injured cells release CYTOKINES
b. attracts WBCs into the tissue

Question 10

Fever:

1. pyrogens are released by ______ targeting the _____ to
   a. increase ____ to promote healing/fight
   b. kill ______
   c. cause ______ and _____ to uptake _____

Answer 10

Fever:

1. pyrogens are released by EOSINOPHILS targeting the HYPOTHALAMUS to
   a. increase METABLOIC RATE OF CELLS to promote healing/fight
   b. kill SOME BACTERIA
   c. cause LIVER and SPLEEN to uptake Fe

Question 11

interleukins:

1. ______ released by mostly macrophages
2. for ______ between WBCs
3. increase ______ _______

Answer 11

interleukins:

1. CYTOKINES released by mostly macrophages
2. for COMMUNICATION between WBCs
3. increase WBC PRODUCTION