Innate Immunity Flashcards
What is the function of the immune system
protect against pathogens
What is the immune system
specialised cell types derived from bone marrow
What are dendritic cells
immune cells in skin
What is the function of dendritic cells
detect antigen and sample extracellular environment
How do dendritic cells elicit immune response
migrate via lymph vessels
What are the primary lymphoid organs
spleen, thymus, bone marrow
What are the peripheral lymphoid organs
lymph node
Who discovered innate immunity
Metchnikoff
Describe the characteristics of the innate immune system
fast, X lag, X memory
What does the innate immune system detect
components or antigens shared by ALL pathogens
Name some physical barriers of the innate immune system
skin, tears, cilia, mucous, stomach, flora
What are the cellular components of the innate immune system
macrophages, lysosomes and phagocytic receptors
How do macrophages kill bacteria
ingest them by phagocytosis
What are the types of pattern recognition receptors
NLRs, TLRs, CLRs, and RLRs
What is the function of pattern recognition receptors
sense pathogens by sensing pattern associated molecular patterns (PAMPs)
What are pattern associated molecular patterns
essential component of pathogens
Where are pattern recognition receptors found
expressed by antigen presenting cells like macrophages or dendritic cells
What is the function of PAMPs
activate PRR causing signalling cascades and protective response
What are defensins
anti-microbial peptides
What is part of the humoral system
defensins, neutrophils
What produces defensins
epithelial cells and phagocytes
What is the function of defensins
kill bacteria by creating pores leading to lysisation
describe the structure of defensins
positively charged side chains and hydrophobic zones
What are the three types of complement system pathways
alternative, classical, lectin
