Environmental Basis of Disease

Question 1

What cancer increased in Japanese migrants to California

Answer 1

colon and prostate

Question 2

What cancer decreased in Japanese migrants to California

Answer 2

stomach and liver

Question 3

What cancers can smoking cause

Answer 3

lung, mouth, throat, bladder, cervix, and kidney

Question 4

Describe the effects of pulmonary emphysema on alveoli

Answer 4

enlargement of alveoli & loss of elastin

Question 5

What environmental factors cause pulmonary emphysema

Answer 5

inhaling toxins

Question 6

What is the effect of genetic and environmental factors on the protease balance in emphysema

Answer 6

genetic - decreases anti-protease, environmental increases protease

Question 7

What are the consequences of pulmonary emphysema

Answer 7

decrease in SA of respiratory membrane causes decreased gas exchange

Question 8

What happens to inhaled air in pulmonary emphysema

Answer 8

trapped in alveoli during exhalation due to NO elastic recoil

Question 9

Name some allergic responses

Answer 9

rhinitis, asthma, extrinsic allergic alveolitis

Question 10

What are the critical factors for pulmonary emphysema

Answer 10

dose of particles, chemical and biological composition, existing health

Question 11

What are the different types of pneumoconiosis reactions

Answer 11

inert, fibrous, and neoplastic

Question 12

What are ferruginous bodies

Answer 12

asbestos fibre, iron and calcium

Question 13

describe the ingestion of asbestos fibres

Answer 13

macrophages ingest asbestos causing a fibrogenic response

Question 14

example of a fibrogenic response

Answer 14

collgaen deposition by fibroblasts