Innate Immunity

Question 1

What is function of eosinophils? (Innate system)

Answer 1

Help combat parasitic infections.
Involved in allergy and asthma.
Granules contain many enzymes.

Question 2

Mast cells and allergy ( eosinophils)?

Answer 2

-Immunogloblin receptors on surface of mast cells
-Receptors expressed by mast cells and antibody recognizes receptor
-any kind of allergen recognized recognised by IgE receptor
-Activates mast cell and releases histamine (mediator)
-activates different kind of tissue
-tissues have receptor for histamine
-triggers specific reaction

Question 3

Function of basophils?

Answer 3

Least common of WBCs (less than 1%)
Contain large cytoplasmic granules with inflammatory mediators.
No proven function
Found in parasitic infection

Question 4

What are cytokines?

Answer 4

Small proteins – secreted by both immune and some nonimmune cells in response to stimulus.
They communicate with other cells
bind to specific receptors on these cells producing a signalling molecules that lead to many biological effects in these cells
Key players in innate and acquired immunity
Differentiation
Activation
Chemotaxis
Enhancing cytotoxicity

Question 5

Cooperating within immune system involving cytokines?

Answer 5

for e.g. receptors on natural killer cells can have LPS attach
(lipopolysaccharide)
-triggers response of NKC
-Interferon-gamma interacts with receptor on phagocyte surface
-similarly , phagocyte recognizes LPS
-triggers reaction of phagocyte
-production of a specific cytokine (TNF) tumour necrosis factor
-TNF binds to TNF receptor of phagocyte
-produces another cytokine (IL12) interleukin 12
-produced massively because stimulated by TNF
-IL12 targets NKC
-promote NKC production of IL2
-IL2 stimulates proliferation of NKC