Inflammatory Mediators: Flashcards
What is arachadonic acid derived from?
Omega-6 fatty acids
What is a metabolite of arachadonic acid?
Prostoglandins
Leukotriene
Where is leukotriene made?
Leukocytes
What do prostoglandins do?
Increased blood flow
Some promote platelet aggregation & vasoconscrition
Chemotaxis
What does leukotriene do?
Increa permeability & constrict smooth muscle
Another name for serotonin?
5-Hydroxytryptamine
Where is serotonin made?
PLatelets during degranulation
What does serotonin do?
Causes Vasoconstriction
What makes histamine?
Platelets
MAst cells
Basophils
What does histamine do?
Causes Vasodilation & increased vascular permeability
What receptors does histamine work on>
H1 on endothelium
B cells do in inflammation?
MEmory B cells
Antibody production
Antigen Presenting
Whats the aciton of macrophages in inflammation?
Antigen Presenting
Debris REmoval
Produces interferon (antiviral)
Whats do T cells do in inflammation?
- Produce cytokines to regulate inflammation
- Lyse cells themselves
- Produce interferon (antiviral)
What do NK cells do in inflammation:
What they always do, fuck shit up.
Destroy foreign cells with granules.
What does ICAM-1 do?
Adheres neutorphils to the endothelial surface
Wjat does P-selectin do?
Interacts with Neutrophil surafces on the endothelium
What is SVR?
Index of arteriolar constriciton throughout the body
What kind of hypersensitivity cusses granulomas?
Type 4
What are foriegn body type giant cells associated wih?
Pyogenic granuloma & implants
How to recognise foreign body type giant cells?
CEntral overlapping nuclei`
Diapedesis?
Movement of blood cells out of capillaries
What vessel changes cause the triple response?
FLush - TRanisent arteriolar constriction
Flare - Local arteriolar dilation
Wheal - Smooth muscle relaxation
