Inflammatory Cytokines

Question 1

What type of cytokine is IL-3??

Answer 1

Haematopoiten

Question 2

What is Chaga’s disease caused by??

Answer 2

Depression in IL-2 receptor

Question 3

What do interleukin 2 do??

Answer 3

1) autocrine growth factor for T and B cells
2) stimulate NK cell cytolytic function
3) induced death of activated T cells

Question 4

What is IL 4 produced by and what does it cause??

Answer 4

T helper 2 cells

1) growth factor for mast cells
2) produces IgG and igE
3) B cell proliferation
4) Th2 cell differentiation

Question 5

What interleukin causes asthma??

Answer 5

IL4

Question 6

What does IL17 cause?

Answer 6

1) pro-inflammatory

2) neutrophil activation

Question 7

What interleukin causes chronic inflammation??

Answer 7

IL17

Question 8

3 functions of interferons alpha and beta??

Answer 8

1) increases resistance to viral replication in cells
2) increases MHC1 expression and antigen presentation
3) activates NK cells

Question 9

What is alpha interferon therapy used for??

Answer 9

Viral hepatitis

Leukaemia

Question 10

What therapy is used for MS??

Answer 10

B-interferon therapy

Question 11

3 functions of TNF-alpha?

Answer 11

1) neutrophil & endothelial cell activation—> inflammation
2) fever
3) cachexia

Question 12

What treats arthritis?

Answer 12

antibodies to TNF

Question 13

Other bacterial response cytokines?? Like TNF

Answer 13

IL1, IL6, IL8, IL12

Question 14

What does transforming GF B do

Answer 14

1) enhances wound repair
2) activates macrophages
3) suppresses lymphocyte

Question 15

What does IL-10 do??

Answer 15

1) suppresses macrophages, T cells and NK cells

2) inhibits TNF, IL1, IL12, chemokine

Question 16

What does an absence of IL10 cause??

Answer 16

IBS