Anti-emetics

Question 1

Name the 3 anti-dopamines, their uses and adverses

Answer 1

1) METOCLOPRAMIDE- dystonia & akathisia
2) DOMPERIDONE- cardiac effects, QT prolongation
3) LEVOMEPROMAZINE -used for malignant bowel obstruction

Question 2

What are anti-histamines used for and when to caution use

Answer 2

Motion sickness

Caution in bladder outflow problems

Question 3

WhT are ondasetron and granisetron?? Uses and adverses

Answer 3

5HT3 receptor antagonists- decrease vagal stimulation to vomiting centre
Used for 1st line chemo/radiotherapy
Caution in QT prolongation and torsades de pointes