AEDS Flashcards
Mechanism of carbamazepine
Na channel blocker
Mechanism of phenytoin
Sodium channel blocker
Mechanism of sodium valproate
Na and calcium channel blocker
Increases GABA decreases glutamate
Mechanism of levetiracetam
SV2a receptor
Blocks vesicle release
Mechanism of lamotrigine
Selective sodium channel blocker
Inhibits glutamate
Mechanism of topiramate
Na and calcium channel blocker decreases glutamate
Increases GABA
Adverses of carbamazepine
fatigue, ataxia, Diplopia, sedation SIADH Bone marrow suppression Rash Hepatic derangement Increases appetite
Adverses of phenytoin
Nystagmus, rash, dizziness, fatigue, ataxia, diplopia, sedation
Coarse face, hirsutism, gum hyperplasia, osteopenia, teratogenicty, decreases folate, peripheral neuropathy
Lymphadenopathy
Adverses of sodium valproate
Increased appetite, liver failure, pancreatitis, reversible hair loss, oedema, tremor, teratogen, thrombocytopenia, encephalopathy
Adverses of levetiracetam
Psychosis Irritability Anxiety Fatigue Dizzy
Adverses of lamotrigine
Insomnia
Stephen Johnson syndrome (rash)
Adverses of topiramate
Anorexia, teratogen, acute angle glaucoma, kidney stones
Treatment for status epilepticus
At 5mins 4mg IV/IM lorazepam (GABA agonist)
At 15mins phenytoin
Epilepsy in pregnancy
Lamotrigine
Levetiracetam
Epilepsy in obesity
Topiramate
Avoid carbamazepine and na valproate