AEDS Flashcards

1
Q

Mechanism of carbamazepine

A

Na channel blocker

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2
Q

Mechanism of phenytoin

A

Sodium channel blocker

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3
Q

Mechanism of sodium valproate

A

Na and calcium channel blocker

Increases GABA decreases glutamate

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4
Q

Mechanism of levetiracetam

A

SV2a receptor

Blocks vesicle release

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5
Q

Mechanism of lamotrigine

A

Selective sodium channel blocker

Inhibits glutamate

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6
Q

Mechanism of topiramate

A

Na and calcium channel blocker decreases glutamate

Increases GABA

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7
Q

Adverses of carbamazepine

A
fatigue, ataxia, Diplopia, sedation
SIADH
Bone marrow suppression 
Rash 
Hepatic derangement 
Increases appetite
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8
Q

Adverses of phenytoin

A

Nystagmus, rash, dizziness, fatigue, ataxia, diplopia, sedation
Coarse face, hirsutism, gum hyperplasia, osteopenia, teratogenicty, decreases folate, peripheral neuropathy
Lymphadenopathy

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9
Q

Adverses of sodium valproate

A

Increased appetite, liver failure, pancreatitis, reversible hair loss, oedema, tremor, teratogen, thrombocytopenia, encephalopathy

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10
Q

Adverses of levetiracetam

A
Psychosis
Irritability 
Anxiety
Fatigue 
Dizzy
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11
Q

Adverses of lamotrigine

A

Insomnia

Stephen Johnson syndrome (rash)

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12
Q

Adverses of topiramate

A

Anorexia, teratogen, acute angle glaucoma, kidney stones

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13
Q

Treatment for status epilepticus

A

At 5mins 4mg IV/IM lorazepam (GABA agonist)

At 15mins phenytoin

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14
Q

Epilepsy in pregnancy

A

Lamotrigine

Levetiracetam

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15
Q

Epilepsy in obesity

A

Topiramate

Avoid carbamazepine and na valproate

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16
Q

Epilepsy in bipolar

A

Lamotrigine

17
Q

Epilepsy in pysch

A

Avoid levetiracetam and topiramate

18
Q

Epilepsy in low bone health

A

Avoid carbamazepine and phenytoin

19
Q

Epilepsy drugs suitable for all seizures

A

Na valproate

20
Q

Epilepsy drug that interacts with all other epileptic drugs

A

Lamotrigine

21
Q

Epilepsy drugs that interact with liver enzyme inducers/inhibitors/OCP

A

Carbamazepine

Phenytoin

22
Q

What does phenytoin interact with

A

Sodium valproate