Dementia/parkinson

Question 1

Name 2 dementia drugs

Answer 1

1-acetylcholinesterase inhibitors
(Donepezil, rivastigmine, galatamine)
2-memantine (NMDA receptor antagonist)

Question 2

Caution acetylcholinesterase inhibitors in…

Answer 2

Sick sinus syndrome/conduction abnormalities
Asthma/COPD
liver impairment and liver and renal impairment in rivastigmine

Question 3

Name 6 Parkinson’s drugs

Answer 3

1- levodopa 
2- dopamine agonists
3-amantadine
4-COMT inhibitors 
5-MAO-B inhibitors 
6-anticholinergic

Question 4

What must levodopa be given with

Answer 4

Dopa decarboxylase inhibitor - carbidopa, benseride (Madopar)

Question 5

Interactions of levodopa

Answer 5

Protein rich meals and vitB6 decrease levodopa

Question 6

Levodopa side effects

Answer 6

Confusion/anxiety
Nausea/vomiting 
Hypotension/arrthymias
Sweating/discolouration of skin/urine 
Dyskinesias long term

Question 7

What is used to treat levodopa off periods

Answer 7

Apomorphine (non ergot derivative dopamine agonist)

Subcutaneous

Question 8

Side effects of dopamine agonists

Answer 8

RETROPERITONEAL/PULMONARY/PERICARDIAL FIBROSIS

nausea/vomiting/arrthmia/hypotension/per oedema/drowsiness/hallucinations/psychotic reactions/poor impulse control

Question 9

Slide effects of amantadine

Answer 9

Peripheral oedema 
LIVEDO RETICULARIS 
arrthymia/hypotension/
Nausea/vomiting
Confusion/anxiety

Question 10

Side effects of anticholinergics

Answer 10

Cognitive impairment 
Blurred vision 
Delirium
Dry mouth
Urinary retention