Antidepressants Flashcards
SSRIs mode of action
Block 5HT receptor reuptake to increase serotonin in the cleft
Side effects of SSRIs
Bleeding Insomnia GI Headache Anxiety Sexual dysfunction Hyponatraemia QT prolongation (citaloplam&escitalopram)
SNRIs mode of action
Block 5HT and noradrenaline reuptake receptor
Side effects of SNRIs
Blood pressure increased at higher doses Insomnia GI Headaches Anxiety Sexual dysfunction Hyponatraemia Sweating QT prolongation in venlaflaxine
NASSAs mode of action
Blocks alpha 2 autoreceptor to block negative feedback so serotonin and noradrenaline increases
Antagonises 5HT2/3 post synaptic receptors to increase 5HT1 activity
Side effects of NASSAs
Drowsiness/ SEDATION Dizzy Weight gain Blood dyscrasia \+QT prolongation (mirtazapine )
Mode of action for tricyclics
Block serotonin/noradrenaline reuptake
Post synaptic blockade of adrenergic/histamine/muscarinic receptors
Side effects of tricyclics
Histamine: hangover/sedation
Alpha 1: arrhythmia/tachycardia/postural hypotension
Ach: dry mouth, constipation
+ QT prolongation ya
What is the only AD that could possibly be used alongside other AD?
NASSA-mirtazapine
Mechanism of monoamine oxidase inhibitors
Block monoamine oxidase so serotonin and noradrenaline isn’t degraded
Side effects of MAOIs
Headaches Hypertensive crisis Hepatotoxicity Anticholinergic effects Parathesia Postural hypotension Insomnia Drowsiness Weight gain Leucopenia
Interactions of MAOIs?
Other AD
john’s wort
Tyramine in foods such as aged cheese, red wine, liver, soy, pickled fish, banana
Vortioxetine mode of action
Serotonin reuptake inhibitor
5HT1 agonist- Post synaptic increases serotonin transmission, pre-synpatic densensitisation of 5HT1A autoreceptors and therefore increases 5HT release
Other serotinergic activity -mediates dopamine, GABA and glutamate release
PRO COGNITIVE EFFECTS
Side effects of vortioxetine
GI
Headaches
Dry mouth
Abnormal dreams
Drugs which prolong QT
Citalopram Escitalopram Venlafaxine Mirfazapine Tricyclics
