Inflammation Flashcards
chemicals sensed by leukocytes in chemotaxis
LFB (exo, bact product)
C5a (endo, chem mediat of inflam)
LTB4 (endo, product of arachidonic acid meta)
IL-8 (endo, cytokine)
what do activated leukocytes do?
- modulate leukocyte adhesion molecules
- phagocytosis
- degranulate
- secrete cytokines that amp and regulate inflam
- produce arachidonic acid metabolites
- aggregate platelets
resolution
replacement of dead cells by cells that were normally there before the inflammatory process
only in tissue w/ regenerative capacity (GI, skin, liver, bone)
granuloma potential diseases
inf agents: TB, leprosy, brucellosis, cat-scratch, fungi
insoluble foreign objects
no known cause: sarcoidosis
plasma derived chem mediators of inflammation
produced in liver, circulate in serum in precursor form FCKK (fuck) factor XII complement proteins clotting proteins kinins
cell derived chem mediators of inflammation
sequestered in cell organelles or produced by effector cells upon stimulation
VLCANO (volcano)
-vasoactive amines (histamine, serotonin) PRE
-lysosomal contents PRE
-cytokines and chemokines (IL-2), TNF) STIM
-arachidonic acid metabolites (prostagladins, leukotrienes, lipoxins) STIM
-NO
-oxygen derived free radicals
contents of azurophil (1*) granules
CAL MED collagenases acid hydrolases lysozyme myeloperoxidase elastase defensins
contents of specific (2*) granules
(c)OLL HAG P collagenase lactoferrin lysozyme histaminase alkaline phosphatase gelatinase plasminogen activator
pyrogens
IL-1, TNFalpha
produced by macrophages
stim release of prostaglandins in hypothal –> resets temp set pt
acute phase reactants
synthesized in liver in response to IL-6
non-specific markers of inflam
c reactive protein, fibrinogen, serum amyloid protein
c reactive protein
marker for acute myocardial infarc
fibrinogen
makes erythrocytes stick together and form stacks
ESR test: higher = more inflam
serum amyloid protein
brings HDL to macrophages for meta
high = increased macrophage activity
cytokines that mediate leukocytosis
IL-1, TNFalpha
cytokines that mediate sepsis
IL-1, TNFalpha
