Gram Neg

Question 1

physiology of enterbacteriaceae (4)

Answer 1

facultative
simple nutritional requirements
ferment glucose
oxidase neg

Question 2

urease

Answer 2

hydrolyzes urea to CO2 and ammonia –> raises local pH

Question 3

type 1 pili

Answer 3

in all e coli strains

attach to host mannose molecules

Question 4

P, PAP (pyelonephritis associated pilus)

Answer 4

attach to host gal-gal molecules
impt in kidney colonization
host receptor is P bl group Ag, large amounts in renal pelvis cells

Question 5

providencia

Answer 5

animal and environmental reservoirs
usually nosocomial inf in cath pts
abx resistance emerging

Question 6

serratia

Answer 6

nosocomial, opportunistic inf
+/- intense red pigment
nonpigmented cause pneumonia, bacteremia, endocarditis in IV drug users ad hospitalized pts

Question 7

definition of diarrhea

Answer 7

frequent stools

often painless, no fever

Question 8

definition of dysentery

Answer 8

pus and blood in stool
frequently painful w/ fever
caused by microbial deep invasion in large intestine

Question 9

enteric fever

Answer 9

systemic inf starting in GI

e.g. typhoid fever caused by salmonella typhi

Question 10

4 most common causes of bacterial enteric disease in US?

Answer 10

1. campylobacter
2. salmonella
3. shigella
4. e coli

Question 11

clinical features of HUS (hemolytic uremia syndrome)

Answer 11

ass;d w/ EHEC, Shigella
Thrombotic microangiopathy
Hemolytic anemia
Thrombocytopenia with renal lesions
Renal failure