Inflamation Flashcards
What are the 5 triggers of inflammation.
1) foreign body
2) infection
3) ischaemia
4) physical or chemical injury
5) immune reaction
Why is inflammation good
Limits tissue injury
Removed dead tissue
Promotes specific immunity
Prepares and initiated for healing and repair
When is inflammation bad
Allergies
What is involved in inflammation
Fluid and proteins
Circulating blood cells
Blood vessels
Constituents of connective tissue
What is a vascular reaction
Increase in vascular permeability = change in flow + vessel calibre occurs to max the movement of plasma proteins and circulating cells to the injury
^ blood flow ^ pressure @ vessels = cells and proteins leak
What is a cellular reaction
WBC extraversion x3 stages
1) margination- cell rolls to activated endothelium
2) transmigration- attaches to walk
3) migration through tissue
WhT are the 3 steps of phagocytosis
1) recognition
2) engulfment
3) killing
What are the cardinal signs of inflammation
Redness Swelling Heat Loss of function Pain
What are the general symptoms of phagocytosis
Fever
Increased bp + hr
Increased wbc + crp
What is acute inflammation
Rapid response short lived
Neutrophils predominantly resolve
Complete resolution healed by fibrosis
E.g burn or infection
What is chronic inflammation
Prolonged inflammation that can develop from acute or persistent infection, prolonged exposure to toxins, autoimmune.
Lymphocytes or macrophages predominant
What meds can be used to manage inflammation
NSAIDs
Anti histamine
Steroid
What are x3 negatives to lack of inflammation
Susceptible to infection
Delay in wound healing
Tissue damage
5 markets of appendicitis
1) 10-30 years old
2) pain localised to right iliac
3) pain worse when move and can cause vomiting
4) Pyrexia increased hr increased wbc increase crp
5) complications = perforation = abscess
What 4 things cause immune system deficiency
1) chemotherapy drugs
2) hiv
3) splenectomy
4) bone marrow dysfunction
