Infections Flashcards

1
Q

C. diff

A

this is a bacterial infection and the most common cause of healthcare associated diarrhoea

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2
Q

presentation of C. diff

A
  • diarrhoea +/- blood

- abdominal pain

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3
Q

what can C. diff progress to?

A
  • pseudomembranous colitis
  • perforation
  • toxic megacolon
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4
Q

diagnosis of C. diff

A
  • screening for organism

- if positive then culture

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5
Q

management of C. diff

A
  • isolate patient
  • less severe= metronidazole
  • severe= vancomycin
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6
Q

presentation of rotavirus

A
  • D&V in children

- dehydration

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7
Q

diagnosis of rotavirus

A

PCR on faeces (sheds)

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8
Q

management of rotavirus

A
  • rehydration, self limiting for about a week
  • vaccine (live attenuated)
    children can get post-infection Mal-absorption leading to more diarrhoea
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9
Q

presentation of norovirus

A

sudden onset D&V

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10
Q

diagnosis of norovirus

A

faeces and vomit swabs for PCR

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11
Q

management of norovirus

A

rehydration

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12
Q

define haemolytic uraemia syndrome (HUS)

A

affects the blood and blood vessels caused by E. coli0157 producing a verotoxin (can progress to kidney failure)

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13
Q

presentation of HUS

A
  • abdominal pain
  • fever
  • pallor, petechiae and obliguria
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14
Q

diagnosis of HUS

A
  • FBC
  • renal function/creatinine
  • stool culture
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15
Q

management of HUS

A
  • dialysis

- blood transfusions

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16
Q

define gastroenteritis

A

infection caused by eating contaminated food

17
Q

presentation of gastroenteritis

A
  • diarrhoea and dysentery
  • fever
  • vomiting
  • cholera “rice-water” like stools
18
Q

diagnosis of gastroenteritis

A
  • stool sample (all stools get salmonella, shigella, E. coli 0157, campylobacter and cryptosporidium and over 4 years gets C. diff)
  • FBC
  • AXR: thumbprint sign
19
Q

management of gastroenteritis

A
  • rehydration

- antidiarrhoeals e.g. bismuth chelate

20
Q

define parasitic infection

A

infection with a parasite e.g. giardiasis lamblia (contaminated water)

21
Q

presentation of giardiasis lamblia

A

abdominal pain, discomfort, nausea

significant malabsorption with weight loss and stearrhoea

22
Q

diagnosis of giardiasis lamblia

A

stool examination for ova and parasites

23
Q

management of giardiasis lamblia

A

metronidazole (1 week)

24
Q

define enteric fever

A

this is caused by salmonella, paratyphoid and typhi (common in Indian subcontinent and SE Asia)

25
Q

presentation of enteric fever

A
  • fever
    -headache
  • constipation or diarrhoea
  • dry cough
    can complication and progress to bleeding and encephalopathy
26
Q

diagnosis of enteric fever

A

blood, urine and stool culture

27
Q

management of enteric fever

A
  • isolate patient

- ciproflaxacin, azithromycin, ceftriaxone (fluoroquinolone for resistance)

28
Q

define Whipple’s disease

A

rare infection with tropheryma whipplei

29
Q

presentation of Whipple’s

A

arthritis
arthralgia
weight loss

30
Q

diagnosis of Whipple’s

A

positive PAS (tissue microscopy)

31
Q

management of Whipple’s

A

trimethroprim

32
Q

define Chaga’s disease

A

infection with trypanosome cruzi that causes parasympathetic depression

33
Q

presentation of Chaga’s

A
  • fever, fatigue, rash
  • nausea, vomiting
    can progress to myocarditis
34
Q

diagnosis of Chaga’s

A

bloods for parasite or antibody

AXR, CXR

35
Q

management of Chagas

A

remove parasite e.g. benznidazole

36
Q

how does giving antibiotics in E. coli 0157 risk development of HUS

A

antibiotic injury to the cell membrane causes massive release of mediators

37
Q

triad in HUS

A

haemolytic anaemia
AKI
thrombocytopenia