Important People

Question 1

Pardee

Answer 1

Field: Cell cycle
Discoveries
* popularized 3T3 mouse cell line (easy to make cancerous)
* to progress through G1, cells need PDGF, then GGF, then insulin in that order
* Pardee point: at G1 checkpoint, either committ to S or go back to G0

Question 2

Ruderman and Hunt

Answer 2

Field: Cell cycle
Discoveries:
* synchronized division of sea urchin emrbyo
* monitored protein synthesis, saw some proteins cycled in abundance (cyclins)

Question 3

Ruth Sager

Answer 3

Field: cell cycle
Discoveries
* proposed that cells have naturally occuring regulatory mechanisms to prevent cancer

Question 4

Rous

Answer 4

Field: cancer
Discoveries
* Sarcoma Virus: retrovirus that causes cancer

Question 5

Robert Weinberg

Answer 5

Field: cancer
discoveries
* Rb: first tumor suppressor gene discovered
* did experiement with human bladder cancer in 3T3 mice cells, saw that genes arent species specific

Question 6

Shina Kamanaka

Answer 6

Field: STEM cells
Discoveries
* Developed induced Pluripotent Stem cells to treat genetic dieseases
* discovered the 4 embryonic master genes that cause a cell to revert to embryonic state (along with James Thomason)
* won nobel prize

Question 7

Levi-Montalcini

Answer 7

field: cell death
observed chick embryo brain cells apoptosis

Question 8

Kerr

Answer 8

Field: cell death
liver ligation experiment
* “shrinking necrosis” apoptosis at center
* necrosis at edges

Question 9

Harvirtz

Answer 9

Field: cell death
discovered apoptotic genes in C. Elegans