Cancer Causes Flashcards
1
Q
Viruses
A
- Sarcoma Virus
- SV40
- EBV (mono)
- HPV
2
Q
Radiation
A
- atomic bomb survivors
- UV light effects thymine-thymine dimers
3
Q
chemical mutagens
A
Tobbacco smoke 60+ mutagens
4
Q
defective cyclins
A
Cyclin D1 over amplified in 50% breast cancer
5
Q
defects in GF pathways
A
RTK mutation
6
Q
Cancer STEM cells (CSC)
A
- in all cancers
- small fraction of tumor
- CD133 marker protein
- recurrence and metastasis
- resistant to chemo and radiation
- treatment: imatinib and HDACi together
7
Q
DNA amplification
A
RTK overproduction, cancer
