Cancer Treatments Flashcards
1
Q
Brachytherapy
A
- Radiation
- radioactive isotope injected near tumor
2
Q
Cyberknife
A
- Radiation
- External Beam Radiation Therapy (EBRT) for brain cancer
3
Q
Da Vinci
A
- Surgical Ablation
- Robotic system for prostate cancer
4
Q
SCN and PSN
A
- Surgical Ablation
- Developed by CPSI biotech
- cryoblation
5
Q
Taxol
A
- chemo drug
- targets microtubules for polymerization
- M checkpoint
6
Q
Taxotere
A
- chemo drug
- synthetic taxol
7
Q
5 Fluorouracil (5-FU)
A
- chemo drug
- adds fluorine to thymine and uracil
- triggers checkpoints
8
Q
Tamoxifen
A
- chemo drug
- competitive antagonist of estrogen receptor
- targets breast cancer
9
Q
Herceptin
A
- biologic
- first mAb
- prevents HER2 dimerizatoin, inhibiting tumor growth
10
Q
Kadycyla
A
- biologic
- herceptin, but with DM1 toxin to apoptose cells
11
Q
Urea
A
- biologic
- used as conjugated Ab
- increase extracellular pH to induce apoptosis
12
Q
Avastin
A
- biologic
- VEGF inhibitor (inhibits blood vessel growth in tumors)
angiogenesis = blood vessel growth
13
Q
Provenge
A
- immunotherapy
- multiplies immune cells, targets prostate cancer
- very expensive, 100k/4 months
14
Q
CAR-T
A
- Immunotherapy
- transfects T-cells with virus giving them genes to produce proteins that attack cancer
15
Q
CAR-T issues
A
- secondary malignancies (positive CAR lymphoma)
- tumor cells can inhibit T-cell function
- targets healthy cells
- toxicity can lead to cell death
- only works on non-solid tumors (90% adult tumors are solid)
