Conditions and Treatments Flashcards
Progeria Condition
Mechanism: Lamin A defect causes Deformed nucleus
Symptoms: Rapid aging
Progeria Treatment
Lonafarnib: Farnesyl transferase inhibitor
HPV Condition
STD virus that causes Cancer
HPV Treatment
Gardasil - “1st Cancer Vaccine” 90%
Erythroleukemia
Normal Condition: EPO with RTK will produce RBCs regulated
Erythroleukemia: SFFV uses glycoprotein 55 to do EPO’s job, unregulated RBC production (RBC Cancer)
RTK Mutations
- NEU oncoprotein binds to HER2
- Valine into glutamine
- causes cancer
SV40 Virus
- Uses DNA
- Large T-Shaped antigen
- effects p53 and Rb, causes cancer
Retinoblastoma
- Rb mutation that can be inherited or not
- found mostly in children
- causes Retina cancer
Li-Fraumeni
- p53 mutation
- 25x increased likelihood of late-life cancer
BRCA-1 Mutation
60% increased likelihood of breast cancer
Listeria
- Non-mobile bacteria becomes mobile once reaching a cell
- nucleates F-actin with its F-actin tail
- can cross the placenta
- causes food poisoning
Epidermolysis Bullosa simplex Condition
- DEB: butterfly children
- Mechanism: defective keratin filaments in basal lamina
- symptoms: skin susceptible to sheer stress and recurring infections
Epidermolysis Bullosa simplex Treatment
Vyjuvek: topically transfects COL7A1 gene, codes for collagen VII to restore skin keratin
Colchicine
- mechanism: depolymerizes microtubules
- used for cancer & gout
Burkitt’s Lymphoma condition
mechanism: chromomal translocation, BCR and ABL genes fused together, causing fused protein that causes many issues
