Immunotherapy Flashcards
What is IV immunoglobulin used for?
Primary and secondary immunodeficiency disorders
What is IV immunoglobulin?
Plasma derived Immunoglobulin G is given IV to replace abnormal or absent
What are indications for IV immunoglobulin?
Primary immunodeficiency Wiskott Aldrich syndrome IgG subclass deficiencies with recurrent infections Idiopathic thrombocytopenic purpura Kawasaki disease CLL Children with HIV Guillain barre syndrome Allogeneic bone marrow transplantation
What is direct immunotherapy?
Antibodies that detect an antigen on tumour cells and destroy the target either by recruiting immune cells or delivering a toxin or radioisotope to it - targets the TUMOUR
What is indirect immunotherapy?
Immune system is activated allowing it to seek and destroy tumour cells - targets the IMMUNE SYSTEM
What can be used for direct immunotherapy?
Monoclonal antibodies
Chimeric antigen receptors
Bi-specific antibodies
What can be used for indirect immunotherapy?
Tumour vaccines Dendritic cell vaccines Adoptive cell transfer Cytokine therapies Checkpoint inhibitor therapies Stimulatory antibodies
What are checkpoint inhibitor therapies?
Work by ‘unlocking’ the immune system, leads to powerful anti tumour responses but potentially immune related adverse effects
What is the main cytokine therapy?
Pegylated IFN-alpha
What is first line treatment for Non-Hodgkin’s lymphoma?
Rituximab
What is infliximab used to treat?
Rheumatoid arthritis
Ankylosing spondylitis
Crohn’s disease
Ulcerative colitis
What is the method of action of infliximab?
Blocks function of tumour necrosis factor alpha
What is herceptin?
Monoclonal antibody - binds to HER2 on cancer cells, marks them out for immune destruction
What is herceptin used to treat?
HER2 positive metastatic breast cancer
What drug is being tested as a checkpoint inhibitor therapy?
Ipilimumab
