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Haematology and immunology > Immunology 1 > Flashcards

Immunology 1 Flashcards

1
Q

What are the 3 main components of the immune system?

A

Chemical/physical barriers
Innate
Adaptive

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2
Q

What does humoral mean?

A

Antibody mediated

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3
Q

What pysical barriers are found within the lung?

A

Muco-ciliary escalator
Surfactant in alveoli
Nasal hairs

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4
Q

What innate immune cells within epithelium will be alerted immediately? (tissue based)

A

Macrophages
Dendritic cells
Mast cells

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5
Q

What cells make up the innate immune system?

A 
Mast cell
Natural killer cell
Basophil
Neutrophil
Eosinophil
Monocyte
Macrophage
Dendritic cell
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6
Q

What innate immune cells are found in the blood?

A

Basophil
Neutrophil
Eosinophil
Monocyte

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7
Q

What is an antigen?

A

A molecle capable of inducing an immune respone

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8
Q

What is an antibody?

A

Glycoprotein produced by B lymphocytes binding to antigens with a high degree of specificity and affinity

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9
Q

What does MHCI present?

A

Intracellular antigens

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10
Q

What does MHCI present to?

A

CD8+ T cells

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11
Q

What does MHCII present to?

A

CD4+ T cells

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12
Q

What cytokines are activated by TH1 cells?

A

IFN gamma

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13
Q

What cytokines are activated by TH2 cells?

A

IL-4
IL-5
IL-13

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14
Q

What cytokines are activated by TH17 cells?

A

IL-17A
IL-17F
IL-22

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15
Q

What are CD8+ cells method of action?

A

Kill by inducing apoptosis in targeted cell

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16
Q

How do NK cells induce apoptosis?

A 
MHC1 expression activates the cell
Release of perforin and granzyme
Perforin creates a pore in cell membrane
Granzyme enters cell
Apoptosis
17
Q

What are the different types of antibody?

A 
IgM
IgG
IgA
IgE
IgD
18
Q

Which antibody can cross the placenta?

A

IgG

19
Q

Which antibody works against parasitic infection and allergy?

A

IgE

20
Q

What does MHCII present?

A

Extracellular antigens

21
Q

What immune reactions are mediated by TH1 cells?

A

Macrophage activation

IgG production

22
Q

What immune reactions are mediated by Th2 cells?

A

Mast cell
Eosinophil
IgE production
Alternative macrophage activation

23
Q

What immune reactions are mediated by Th17 cells?

A

Neutrophilic and monocytic inflammation

Haematology and immunology (19 decks)

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