Immunology Exam 2 Flashcards
1
Q
Gumma
A
Painful immune tumors associated with Tertiary Syphilis
2
Q
Latent Syphilis can be found in
A
Bone marrow
lymph glands
vital organs
central nervous system (CNS)
3
Q
Darkfield Exam
A
- Used in detection of primary and secondary syphilis
- Looking for rapid motility
4
Q
VDRL Heat Inactivation
A
- Heat serum to 56C for 30 min to destroy complement
- If repeat testing, must re-heat for 10 min
5
Q
RPR stands for
A
Rapid Plasma Reagin
6
Q
RPR adds _____ to VDRL
A
- Charcoal for visualization
- Choline Chloride to destroy complement
7
Q
FTS-ABS
A
- Indirect fluorescent antibody test
- Confirmatory test
- Reiter strain as a sorbent
- Nichols strain adsorbed to slide
- 80% positive in Primary Siphilis, 100% by secondary, antibodies for life
8
Q
Relapsing Fever (Epidemic)
A
- Causitive agent: Bornelia recurrentis
- Widespread
- Lice vector
9
Q
Relapsing Fever (Endemic)
A
- Causitive agent: Borrelia spp.
- Pockets of infection
- Soft-shell tick vector
10
Q
Lyme’s Disease
A
- Causitive agent: Borrelia burgdorferi
- Hard-shell tick vector
- “Bulls-eye” rash
- Flu-like and neurological symptoms
11
Q
Relapsing fever microbe also seen by
A
Hematology - spirochete on Wright’s Stain
12
Q
Treatment for Lyme’s Disease
A
- Doxycycline followed by amoxicillin
- Neuroborreliosis requires IV antibiotics
13
Q
Lyme’s Disease Tests
A
- EIA
- IFA
- Western Blot
14
Q
Western Blot for Lyme’s Disease
A
Detects Outer Surface Protein
- 23-25 kDa (Osp C)
- 31 kDa (Osp A)
- 34 kDa (Osp B)
- 39 kDa
- 41 kDa
- 83-89 kDa
15
Q
Blood Supply is screened for:
A
- HepB
- HepC
- HTLV-1
- West Nile Virus
- Chagas Disease
- CMV