Immunology

Question 1

Lysozymes in tears destroy ___ and so are protective against __+__

Answer 1

Cell walls
Gram -ves
Funghi

Question 2

___+___ in tears are a defence against gram +ves

Answer 2

Lactoferrin

Transferrin

Question 3

Chemical defences in tears =(10)

Answer 3

Lysozyme
Lactoferrin and transferrin
Lipids
Angiogenin
IgA
Complement
IL6+8+MIP

Question 4

Immune cells in the eye (3)

Answer 4

Neutros (by chemotaxis)
Macrophages
Conjunctival mast cells (vasoactive mediators)

Question 5

Principle APC for external eye

Answer 5

Langerhans cells

Question 6

Langerhans cells in eye are abundant at ____, less so at ___ and absent from ____

Answer 6

Abundant - corneo-scleral limbus
Less - peripheral cornea
None - central 2/3 cornea

Question 7

Only part of eye with lymphatic drainage

Answer 7

Conjunctiva

Question 8

Conjunctiva has ____ for regulated migration of lymphoid cells

Answer 8

Specialised endothelial venules

Question 9

Components of immunity at the conjunctiva

Answer 9

CD4+ and 8+ and IgA secreting plasma cells
Dendritic cells
MALT - macros Langerhans and mast cells
Commensal bacteria
Neutros and eosinos if recruited

Question 10

Cornea and sclera have a ____ immune envnt

Answer 10

Downregulated

Question 11

Immune cells in lacrimal gland

Answer 11

More IgA plasma cells and CD8+ than conjunctiva
T cells in small groups around intralobar ducts
MALT

Question 12

Vitreous choroid and retina have a ___ immune envnt

Answer 12

Downregulated

Question 13

Immune privileged sites definition

Answer 13

Tolerate introduction of antigens wo eliciting an inflammatory immune response

Question 14

Immune privileged sites in the body?

Answer 14

Brain/CNS
Testes
Placenta/foetus
Eyes - cornea, ant chamber, lens, vitreous cavity, sub retinal space

Question 15

ACAID aka

Definition =

Answer 15

Anterior chamber associated immune deviation
Generation of primed CD4+ and Bs that produce not complement fixing Igs
Also inhibition of Type 4 HS and Bs that secrete complement fixing Igs

Question 16

Features of immune privileged sites

Answer 16

Blood tissue barrier
Lack of direct lymphatic drainage
Immunosuppressive and inhibitory cell surface proteins
ACAID

Question 17

Establishment of immune privilege in the eye(3)

Answer 17

Immunological ignorance (corneal cells have decreased expression of MHCI and none of II)
Immunosuppressive envnt
ACAID

Question 18

Sympathetic ophthalmia =

Answer 18

Rare bilateral agranulomatous uveitis due to trauma of one eye

Question 19

In sympathetic ophthalmia is an initial wave of ___ and then an infiltration wave of ___ cells

Answer 19

CD4+

CD8+

Question 20

In sympathetic ophthalmia
Injured eye =
Other =

Answer 20

Excited eye

Sympathising eye

Question 21

Dalen Fuchs nodule -

Answer 21

AI cause

Epithelial cell clusters in retinal layer

Question 22

Type 1 HS reaction in the eye eg.

Feature =

Answer 22

Acute allergic conjunctivitis

Chemosis

Question 23

Type 2 HS of the eye eg

Features =

Answer 23

Ocular cicatricial pemphigoid

AI conjunctivitis =>. It blisters and scars

Question 24

Type 3 HS of the eye eg.

Answer 24

AI corneal melting

Question 25

Type 4 HS eg of the eye

Answer 25

Corneal graft rejection

Question 26

What type of HS is immune complex mediated

Answer 26

3

Question 27

What type of HS reaction is direct cell killing/Ig mediated cytotoxic?

Answer 27

2

Question 28

2 ocular side effects of steroids

Answer 28

Glaucoma

Cataracts