Immunology Flashcards
Lysozymes in tears destroy ___ and so are protective against __+__
Cell walls
Gram -ves
Funghi
___+___ in tears are a defence against gram +ves
Lactoferrin
Transferrin
Chemical defences in tears =(10)
Lysozyme Lactoferrin and transferrin Lipids Angiogenin IgA Complement IL6+8+MIP
Immune cells in the eye (3)
Neutros (by chemotaxis)
Macrophages
Conjunctival mast cells (vasoactive mediators)
Principle APC for external eye
Langerhans cells
Langerhans cells in eye are abundant at ____, less so at ___ and absent from ____
Abundant - corneo-scleral limbus
Less - peripheral cornea
None - central 2/3 cornea
Only part of eye with lymphatic drainage
Conjunctiva
Conjunctiva has ____ for regulated migration of lymphoid cells
Specialised endothelial venules
Components of immunity at the conjunctiva
CD4+ and 8+ and IgA secreting plasma cells Dendritic cells MALT - macros Langerhans and mast cells Commensal bacteria Neutros and eosinos if recruited
Cornea and sclera have a ____ immune envnt
Downregulated
Immune cells in lacrimal gland
More IgA plasma cells and CD8+ than conjunctiva
T cells in small groups around intralobar ducts
MALT
Vitreous choroid and retina have a ___ immune envnt
Downregulated
Immune privileged sites definition
Tolerate introduction of antigens wo eliciting an inflammatory immune response
Immune privileged sites in the body?
Brain/CNS
Testes
Placenta/foetus
Eyes - cornea, ant chamber, lens, vitreous cavity, sub retinal space
ACAID aka
Definition =
Anterior chamber associated immune deviation
Generation of primed CD4+ and Bs that produce not complement fixing Igs
Also inhibition of Type 4 HS and Bs that secrete complement fixing Igs
Features of immune privileged sites
Blood tissue barrier
Lack of direct lymphatic drainage
Immunosuppressive and inhibitory cell surface proteins
ACAID
Establishment of immune privilege in the eye(3)
Immunological ignorance (corneal cells have decreased expression of MHCI and none of II)
Immunosuppressive envnt
ACAID
Sympathetic ophthalmia =
Rare bilateral agranulomatous uveitis due to trauma of one eye
In sympathetic ophthalmia is an initial wave of ___ and then an infiltration wave of ___ cells
CD4+
CD8+
In sympathetic ophthalmia
Injured eye =
Other =
Excited eye
Sympathising eye
Dalen Fuchs nodule -
AI cause
Epithelial cell clusters in retinal layer
Type 1 HS reaction in the eye eg.
Feature =
Acute allergic conjunctivitis
Chemosis
Type 2 HS of the eye eg
Features =
Ocular cicatricial pemphigoid
AI conjunctivitis =>. It blisters and scars
Type 3 HS of the eye eg.
AI corneal melting
Type 4 HS eg of the eye
Corneal graft rejection
What type of HS is immune complex mediated
3
What type of HS reaction is direct cell killing/Ig mediated cytotoxic?
2
2 ocular side effects of steroids
Glaucoma
Cataracts
