Immunology Flashcards
What are the myeloid cells
Cells that would be produced in the Bone marrow but would move to mature in the body
What is the difference between the innate and the adaptive immune system
Innate: slower and non-specific
Adaptive: cleaner and more specific
Where are the T and B cells produced
The bone marrow
Where do the T and B cells mature
T cells in the thymus
B cells in the lymph nodes
What happens during T cells maturation
Lymphoid progenitor cells enters the thymus
DN when not got CD4 or CD8. Becomes a DP when got these
DP interacts with the cortical epithelial cell and recognises either MHC1/MHC2
Those that do not interact would be neglected, die
Depending which one becomes committed to CD4/CD8
Enters the medulla if attaches to the dendritic cells antigens would be killed
What is special about the MHC1 and MHC 2
MHC1 would be for the nucleated cells
MHC2 would be for the antigen presenting cells
What are the chemoattractants
Would attract the phagocyte to the site where needed
What is the difference between the location of the monocytes and the macrophages
Macrophages are in the tissues
Monocytes are in circulation
What is the difference between the red bone marrow and the yellow bone marrow
Red bone marrow: contains the red blood cells and some white blood cells
Yellow bone marrow: white blood cells and fats (mainly in the adults and in the long bones of the body)
What are osteoclasts
Would mineralise the bone
Releasing the useful bone minerals to which they can be used
What are the 4 tonsilar structures
Adenoids (pharyngeal tonsil) - roof of mouth
Tubal tonsil - underneath the adenoid
Palatine - back of mouth (the normal tonsil that you see)
Lingual tonsil - at the bottom
What are the cells in the tonsils and why are they special?
M cells that would be U-shaped
This would allow the lymphocytes, b and t cells to enter, killing the pathogen
Underneath these cells would be a lymph node that would release the B cells to the epithelium of the tonsils
What lymphoid tissue are the tonsils associated with
MALT
Mucosa Associated Lymphoid Tissue
What are the functions of the spleen
-kill old erythrocytes
-antibody synthesis can occur
-filter for the blood
-not killing the bacteria but would kill the the senescent (old) cells
In what way is inflammation good
Attracts the defence cells to the area
Allowing the pathogen or the damaged cells to be destroyed
AIDS with health
