Immunology Flashcards

1
Q

SLE is an example of which type of immune reaction?

A

Type 3 hypersensitivity
Immune complex deposition

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2
Q

What in cervical secretions attack bacterial lipoprotein?

A

Lysozymes

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3
Q

Which antigen presenting cell is in the cervix?

A

Langerhans Cells
(a type of macrophage)

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4
Q

Cytokine involved in OHSS

A

VEGF

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5
Q

Allergy Ig

A

IgE

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6
Q

Plasma cells originate from what type of cells

A

B lymphocytes

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7
Q

What is the effect of prostacyclin
aka prostaglandin PGI2

A

vasodilator

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8
Q

Which hormone is insensitive to NSAIDS and a potent inflammatory mediator?

A

Bradykinin

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9
Q

Which of the following is the primary opsonin in the complement system?

A

C3b

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10
Q

Which of the following is the main immunoglobulin in the gut and secretions (saliva, milk, tears) and is important in mucosal immunity?

A

IgA

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11
Q

Which cells secrete both heparin and histamine?

A

mast cells

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12
Q

What is the origin in the body of T and B Lymphocytes?

A

Bone Marrow

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13
Q

Which class I major histocompatibility complex human leucocyte antigen (HLA) is expressed only in extravillous trophoblast?

A

HLA-G

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14
Q

What is the alternate complement pathway initiated by?

A

Microorganisms

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15
Q

Inflammatory phase of wound healing, predominant cell type

A

PMN
polymorphonuclear neutrophils

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16
Q

Which immunoglobulin is a key to passive neonatal immunity?

17
Q

What type of cell is a NK cell?

A

Lymphocyte

18
Q

Which antibody is a dimer

19
Q

Macrophages are derived from what type of cell?

20
Q

Most important complement in opsonization

21
Q

Which class I major histocompatibility complex human leucocyte antigen (HLA) is not expressed in extravillous trophoblast?

A

HLA A
&
HLA B

22
Q

Pentamer shaped immunoglobulin

A

IgM

5 points on the letter ‘M’

23
Q

Why does rheumatoid arthritis improve in pregnancy

A

Because there is
Downregulation of TH1 (cell mediated i.e. cytotoxic T, NK)

Remember there is also
Upregulation of TH2 (humoral or B lymphocyte and antibody mediated)

24
Q

What type of cells are NK cells

A

Lymphocytes

25
Name some phagocytes
Macrophages Neotrophils
26
What percentage of WBC are lymphocytes
20 - 40%
27
What is another name for CD4 cells
T helper cells
28
What complement initiates the cascade
C3 C3a/[C3b] C5a/[C5b] C6-9 form membrane attack complex
29
Which is downregulated in pregnancy Th1 (cell mediated) NK etc Th2 (Humoral) B etc
Th1 (cell mediated) is downregulated
30
How does IgG move across placenta?
Active transport
31
What side of the complement pathway is activated by antigen and antibody complexes?
The classic pathway