Immunology Flashcards
SLE is an example of which type of immune reaction?
Type 3 hypersensitivity
Immune complex deposition
What in cervical secretions attack bacterial lipoprotein?
Lysozymes
Which antigen presenting cell is in the cervix?
Langerhans Cells
(a type of macrophage)
Cytokine involved in OHSS
VEGF
Allergy Ig
IgE
Plasma cells originate from what type of cells
B lymphocytes
What is the effect of prostacyclin
aka prostaglandin PGI2
vasodilator
Which hormone is insensitive to NSAIDS and a potent inflammatory mediator?
Bradykinin
Which of the following is the primary opsonin in the complement system?
C3b
Which of the following is the main immunoglobulin in the gut and secretions (saliva, milk, tears) and is important in mucosal immunity?
IgA
Which cells secrete both heparin and histamine?
mast cells
What is the origin in the body of T and B Lymphocytes?
Bone Marrow
Which class I major histocompatibility complex human leucocyte antigen (HLA) is expressed only in extravillous trophoblast?
HLA-G
What is the alternate complement pathway initiated by?
Microorganisms
Inflammatory phase of wound healing, predominant cell type
PMN
polymorphonuclear neutrophils
Which immunoglobulin is a key to passive neonatal immunity?
IgG
What type of cell is a NK cell?
Lymphocyte
Which antibody is a dimer
IgA
Macrophages are derived from what type of cell?
Monocytes
Most important complement in opsonization
C3b
Which class I major histocompatibility complex human leucocyte antigen (HLA) is not expressed in extravillous trophoblast?
HLA A
&
HLA B
Pentamer shaped immunoglobulin
IgM
5 points on the letter ‘M’
Why does rheumatoid arthritis improve in pregnancy
Because there is
Downregulation of TH1 (cell mediated i.e. cytotoxic T, NK)
Remember there is also
Upregulation of TH2 (humoral or B lymphocyte and antibody mediated)
What type of cells are NK cells
Lymphocytes
Name some phagocytes
Macrophages
Neotrophils
What percentage of WBC are lymphocytes
20 - 40%
What is another name for CD4 cells
T helper cells
What complement initiates the cascade
C3
C3a/[C3b]
C5a/[C5b]
C6-9 form membrane attack complex
Which is downregulated in pregnancy
Th1 (cell mediated) NK etc
Th2 (Humoral) B etc
Th1 (cell mediated) is downregulated
How does IgG move across placenta?
Active transport
What side of the complement pathway is activated by antigen and antibody complexes?
The classic pathway
