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P1EXAM > Immunology > Flashcards

Immunology Flashcards

1
Q

SLE is an example of which type of immune reaction?

A

Type 3 hypersensitivity
Immune complex deposition

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2
Q

What in cervical secretions attack bacterial lipoprotein?

A

Lysozymes

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3
Q

Which antigen presenting cell is in the cervix?

A

Langerhans Cells
(a type of macrophage)

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4
Q

Cytokine involved in OHSS

A

VEGF

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5
Q

Allergy Ig

A

IgE

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6
Q

Plasma cells originate from what type of cells

A

B lymphocytes

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7
Q

What is the effect of prostacyclin
aka prostaglandin PGI2

A

vasodilator

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8
Q

Which hormone is insensitive to NSAIDS and a potent inflammatory mediator?

A

Bradykinin

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9
Q

Which of the following is the primary opsonin in the complement system?

A

C3b

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10
Q

Which of the following is the main immunoglobulin in the gut and secretions (saliva, milk, tears) and is important in mucosal immunity?

A

IgA

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11
Q

Which cells secrete both heparin and histamine?

A

mast cells

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12
Q

What is the origin in the body of T and B Lymphocytes?

A

Bone Marrow

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13
Q

Which class I major histocompatibility complex human leucocyte antigen (HLA) is expressed only in extravillous trophoblast?

A

HLA-G

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14
Q

What is the alternate complement pathway initiated by?

A

Microorganisms

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15
Q

Inflammatory phase of wound healing, predominant cell type

A

PMN
polymorphonuclear neutrophils

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16
Q

Which immunoglobulin is a key to passive neonatal immunity?

A

IgG

17
Q

What type of cell is a NK cell?

A

Lymphocyte

18
Q

Which antibody is a dimer

A

IgA

19
Q

Macrophages are derived from what type of cell?

A

Monocytes

20
Q

Most important complement in opsonization

A

C3b

21
Q

Which class I major histocompatibility complex human leucocyte antigen (HLA) is not expressed in extravillous trophoblast?

A

HLA A
&
HLA B

22
Q

Pentamer shaped immunoglobulin

A

IgM

5 points on the letter ‘M’

23
Q

Why does rheumatoid arthritis improve in pregnancy

A

Because there is
Downregulation of TH1 (cell mediated i.e. cytotoxic T, NK)

Remember there is also
Upregulation of TH2 (humoral or B lymphocyte and antibody mediated)

24
Q

What type of cells are NK cells

A

Lymphocytes

25
Q

Name some phagocytes

A

Macrophages
Neotrophils

26
Q

What percentage of WBC are lymphocytes

A

20 - 40%

27
Q

What is another name for CD4 cells

A

T helper cells

28
Q

What complement initiates the cascade

A

C3
C3a/[C3b]
C5a/[C5b]
C6-9 form membrane attack complex

29
Q

Which is downregulated in pregnancy
Th1 (cell mediated) NK etc
Th2 (Humoral) B etc

A

Th1 (cell mediated) is downregulated

30
Q

How does IgG move across placenta?

A

Active transport

31
Q

What side of the complement pathway is activated by antigen and antibody complexes?

A

The classic pathway

P1EXAM (27 decks)

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