Immunology Flashcards
1
Q
Components of innate immune system
A
- Immune cells -
- - Physical & biochemical barriers -
- - Humoral defenses e.g., complement system
2
Q
Immune cells of innate immune system
A
- Granulocytes (neutro, eosin & basophils)
- NK cells***
- Mast cells***
- APCs - macrophages
- dendritic cells***
3
Q
APCs
A
- Macrophages
2. Dendritic cells
4
Q
Features of skin
A
- Dry - tough & dead keratinized cells
- Acidic - sebum from hair follicles
- Sheds frequently
- Lysozyme from sweat
5
Q
Pathways which activate complement system
A
- Classical: Ab-Ag complex
- ————-2. Lectin: mannose————– - Alternative: LPS
6
Q
How do normal flora prevent infection under normal circumstances?
A
- Competition for nutrients & space
- Release of harmful substances
- Alterations of pH & availability of oxygen
7
Q
What do Pattern Recognition Receptors (PRRs) recognize?
A
- Pathogen-associated Molecular Patterns (PAMPs)
2. Damage-associated Molecular Patterns (DAMPs)
8
Q
E.g. of PRRs
A
- Toll-like receptors
- NLRs
- RLRs
- Mannose-binding lectin
- Macrophage mannose receptors
- Scavenger receptors
- NODs
- CLRs
9
Q
TLR-3, RIG-1 & AIM-2
A
Viral double-stranded RNA
10
Q
TLR-7 & 8
A
Viral single-stranded RNA
11
Q
TLR-9**
A
Bacterial DNA
12
Q
TLR-4**
A
LPS on gram - bac
13
Q
TLR-5 & NLRC-4
A
Bac flagellin
14
Q
TLR-1, 2 & 6
A
Bac lipoproteins
15
Q
NOD-1 & 2 & NLRP-1
A
Peptidoglycans on gram + bac
