Drugs for Dyslipidemia Flashcards
1
Q
Inhibits HMG-CoA reductase
A
ATORVAstatin
2
Q
Mechanism of action of Atorvastatin
A
- Competitive inhibition of HMG-CoA reductase
- HMG-CoA reductase unable to convert HMG-CoA to mevalonate
- Intrahepatic cholesterol biosynthesis reduced
- LDL receptor upregulation
3
Q
Should you prescribe a pregnant woman or a woman hoping to conceive atorvastatin?
A
No
4
Q
Atorvastatin is hepatotoxic as it may cause elevation in level of enzyme ___.
A
aminotransferase
5
Q
Additional characteristics of atorvastatin
A
- Anti-inflammatory
- Anti-thrombotic
- Antioxidant
6
Q
Describe MOA of clofibrate
A
- Activation of PPAR-a
- Increased LIPOPROTEIN LIPASE (LPL)
- Increased degradation VDL/triglycerides & HDL synthesis
7
Q
LDL may increase if triglycerides decrease. True/False?
A
True
8
Q
Bile acid sequestrants
A
Cholestyramine
9
Q
MOA of bile acid sequestrants
A
- Inhibits bile acid resorption
- Increases conversion of cholesterol into bile acid
- LDL receptor upregulation
10
Q
Ezetimibe (ee-zeh-tee-muhb)
A
Inhibits intestinal absorption of cholesterol
11
Q
State 2 other MOA of niacin
A
- In adipose tissues, niacin inhibits lipolysis by inhibiting hormone-sensitive lipase (HSL)
- This decreases transport of free fatty acids (FFAs) to liver
- This decreases substrates available for synthesis of triglycerides in liver
- This decreases levels of VLDL & LDL & increases levels of HDL***
- ——— - Enhances lipoprotein lipase (LPL) activity
- Increases levels of HDL by decreasing clearance of HDL
12
Q
Best agent for increasing HDL
A
Niacin
13
Q
Niacin increases synthesis of ___.
A
prostaglandin
14
Q
To minimize flushing due to niacin, patient can take ___.
A
aspirin
15
Q
PCSK9 inhibitor
A
Alirocumab
