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BMRD > Adrenergic Pharmacology > Flashcards

Adrenergic Pharmacology Flashcards

1
Q

Which adrenergic receptors do isoprenaline stimulate?

A

b1 & b2

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2
Q

a1 agonist

A

Phenylephrine

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3
Q

b2 agonist

A

Salbutamol

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4
Q

b1 agonist

A

Dobutamine

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5
Q

Effects of stimulating a1 receptors

A
  1. Vasoconstriction 2
  2. Contraction of dilator muscle of eye & bladder sphincter 2
  3. Glycogenolysis 1
  4. Renin unreleased 1
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6
Q

Effect of stimulating a2 receptors

A

Decreases insulin secretion

Bradycardia

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7
Q

a2 agonist

A

Clonidine

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8
Q

Effects of stimulating b1 receptors

A
  1. Increases cardiac performance

2. Increases renin secretion & thus BP

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9
Q

Effects of stimulating b2 receptors

A
  1. Vasodilation of blood vessels of skeletal muscles 1
  2. Bronchodilation 1
  3. Increase in secretion of insulin pic 1
  4. Reduced GI motility pic 2
  5. Relaxation of SMCs of uterus pic 3
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10
Q

High concentration adrenaline stimulates which receptor?

A

a receptor

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11
Q

Low concentration adrenaline stimulates which receptor?

A

b receptor

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12
Q

Low concentration of dopamine stimulates which receptor?

A

D1 receptor

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13
Q

Moderate concentration of dopamine stimulates which receptor?

A

b1 receptor

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14
Q

High concentration of dopamine stimulates which receptor?

A

a1 receptor

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15
Q

Effects of clonidine

A
  1. Suppresses sympathetic NS
  2. Activates parasympathetic NS
  3. Bradycardia
  4. Decrease in BP
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16
Q

Adrenergic releasing agent

A

Amphetamine

17
Q

Mixed acting adrenergic drug

A

Ephedrine

18
Q

Nature of ephedrine

A

Non-selective adrenergic agonist

NE releasing agent

19
Q

Reversible non-selective a blocker

A

Phentolamine

20
Q

Irreversible non-selective a blocker

A

Phenoxylbenzamine

21
Q

Selective a1 blockers

Hint: sin

A

Prazosin

Tamsulosin

22
Q

Effects of a2 receptor blockade

A

Inhibits negative feedback –> NE release increases –> sympathetic outflow increases

Tachycardia

23
Q

What is used to treat hypertension due to pheochromocytoma?

A

Phenoxylbenzamine

24
Q

What is used to treat benign hypertrophy of prostate?

A

Tamsulosin

25
Q

Non-selective b blocker w/o ISA

A

Propranolol

26
Q

Non-selective b blocker w/ ISA

A

Pindolol

27
Q

Cardio-selective b blocker

A

Metoprolol

28
Q

What is the effect of stimulating D1 receptor w/ low dose of dopamine?

A

Vasodilation of renal blood vessels thus increasing renal blood flow

29
Q

Phenylephrine

A

a1 agonist

BMRD (18 decks)

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