Adrenergic Pharmacology Flashcards
Which adrenergic receptors do isoprenaline stimulate?
b1 & b2
a1 agonist
Phenylephrine
b2 agonist
Salbutamol
b1 agonist
Dobutamine
Effects of stimulating a1 receptors
- Vasoconstriction 2
- Contraction of dilator muscle of eye & bladder sphincter 2
- Glycogenolysis 1
- Renin unreleased 1
Effect of stimulating a2 receptors
Decreases insulin secretion
Bradycardia
a2 agonist
Clonidine
Effects of stimulating b1 receptors
- Increases cardiac performance
2. Increases renin secretion & thus BP
Effects of stimulating b2 receptors
- Vasodilation of blood vessels of skeletal muscles 1
- Bronchodilation 1
- Increase in secretion of insulin pic 1
- Reduced GI motility pic 2
- Relaxation of SMCs of uterus pic 3
High concentration adrenaline stimulates which receptor?
a receptor
Low concentration adrenaline stimulates which receptor?
b receptor
Low concentration of dopamine stimulates which receptor?
D1 receptor
Moderate concentration of dopamine stimulates which receptor?
b1 receptor
High concentration of dopamine stimulates which receptor?
a1 receptor
Effects of clonidine
- Suppresses sympathetic NS
- Activates parasympathetic NS
- Bradycardia
- Decrease in BP
Adrenergic releasing agent
Amphetamine
Mixed acting adrenergic drug
Ephedrine
Nature of ephedrine
Non-selective adrenergic agonist
NE releasing agent
Reversible non-selective a blocker
Phentolamine
Irreversible non-selective a blocker
Phenoxylbenzamine
Selective a1 blockers
Hint: sin
Prazosin
Tamsulosin
Effects of a2 receptor blockade
Inhibits negative feedback –> NE release increases –> sympathetic outflow increases
Tachycardia
What is used to treat hypertension due to pheochromocytoma?
Phenoxylbenzamine
What is used to treat benign hypertrophy of prostate?
Tamsulosin
Non-selective b blocker w/o ISA
Propranolol
Non-selective b blocker w/ ISA
Pindolol
Cardio-selective b blocker
Metoprolol
What is the effect of stimulating D1 receptor w/ low dose of dopamine?
Vasodilation of renal blood vessels thus increasing renal blood flow
Phenylephrine
a1 agonist