ADRs Flashcards
Pregnancy category C w/ e.g.
Animal x
Human N/A
E.g., morphine
Pregnancy category B w/ e.g.
Animal _/
Human N/A
E.g., erythromycin (antibiotic)
Pregnancy category D w/ e.g.
Human x
Benefit > risk
E.g. antiepileptics
Penicillin & A compete for renal drug transporters thus affecting B.
A: probenecid
B: excretion
A, B & C increase hepatic metabolism.
A: phenytoin
B: rifampicin
C: barbiturates
A & B decrease hepatic metabolism by inhibiting drug-metabolizing enzymes.
A: cimetidine
B: erythromycin
___ decreases hepatic blood flow.
Propranolol
A displace warfarin from binding site thus affecting B of C.
A: sulphonamides
B: distribution
C: warfarin
How does adrenaline prolong effect of LA?
Adrenaline decreases absorption of LA
A & antimuscarinics B GI motiliy and hence absorption.
A: metoclopramide
B: decreases
A & B decrease drug absorption by binding drug.
A: antacids
B: tetracyclines
A + B = cotrimoxazole
A: sulfaMETHOxazole
B: triMETHOprim
Cranberry juice inhibits CYP2C9 thus increasing bioavailability of ___.
Warfarin
Broccoli & spinach which contain vit. K reduce effect of ___.
Warfarin
