Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

BMRD > General Pharmacology > Flashcards

General Pharmacology Flashcards

1
Q

Bioavailability

A

Extent to which drug reaches plasma/site of action unchanged

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Factor of bioavailability

A

Route of administration

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What does Vd tell you?

A

Lipid solubility

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Diff between clearance & rate of elimination?

A

Clearance: Vplasma cleared of drug per unit time

Rate of elimination: amount of drug removed per unit time

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Higher Vd, ___ half life. Why?

A

Longer cos stay in tissue longer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Steady state concentration

A

Rate of drug in = rate of drug out

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Difference between graded & quantal DRC?

A

Graded: individual study
Quantal: populational study

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Efficacy

A

Ability of drug to produce max response

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Potency

A

Dose needed to produce given response

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Lower ED50, ___ potent drug

A

More

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Efficacy depends on?

A

Number of efficacious drug-receptor interaction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Types of antagonist

A

(Non)-competitive

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

In presence of competitive antagonist, DRC ___

A

Shifts parallelly to right

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Potency changes in presence of non-competitive antagonist. True/False?

A

False

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Efficacy ___ in presence of non-competitive antagonist.

A

Decreases

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Therapeutic index indicates ___.

A

How much room to play w/ dose

17
Q

A cholinergic drug which causes miosis & is used to treat glaucoma

A

Pilocarpine

18
Q

A drug used to differentiate myasthenic crisis from cholinergic crisis

A

Edrophonium

19
Q

A drug used in the treatment of hypertension but is contradicted if patient has bronchial asthma

A

Propranalol

20
Q

A drug used for symptomatic treatment of organophosphate poisoning

A

Atropine

21
Q

Pilocarpine effects

A
  1. Miosis (constriction of pupil)
  2. Cyclospasm (accommodation of focus for near vision)
  3. Lowering of IOP
22
Q

A drug used in the treatment to reverse muscle paralysis induced by non-polarizing neuromuscular blockers

A

Neostigmine

23
Q

Atropine is (non-competitive/competitive) antagonist for muscarinic receptors

A

Competitive

24
Q

A drug used in the treatment to reverse muscle paralysis induced by non-depolarizing neuromuscular blockers

A

Neostigmine

25
Q

Atropine is (non-competitive/competitive) antagonist for muscarinic (x nicotinic) receptors

A

Competitive

26
Q

Difference between atropine & pralidoxime

A

Atropine: symptomatic treatment
Pralidoxime: root of problem

27
Q

Why propranolol aggravates bronchial asthma?

A

Propranolol is non-selective beta blocker

28
Q

Which is 1st choice for hypertension: propranolol or metoprolol?

A

Metoprolol

29
Q

Which is 1st choice for hypertension: propranolol or metoprolol? Why?

A

Metoprolol because cardioselective

BMRD (18 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions