Immuno Flashcards
Low IgM, raised IgA and IgE
Wiskott Aldrich
Mouse Ab targetted at CD3 to treat rejection in allograft pts
OKT3
Inhibits calcineurin –> inhibits IL-2
Cyclosporine A
Anti Jo1
Dermatomyositis
Anti SM ab
AI hepatitis
TI hypersensitivity
Strong CD4+ Th2 response
IL-4 and IL-12
B cells
IgE
Mast cells
What type HS reaction is extrinsic allergic alveolitis
III
Farmer’s lung (mouldy hay)
INhibits RANK L
Denosumab
Berger’s disease =
IgA nephropathy
Deficiency in NAPDH oxidase
CGD
Absent respiratory burst
First cytokine in Type IV HS reactions
IL-12 from macrophages
Tx for Bruton’s
IgG
Myesthaenia gravis Tx
plasmapheresis
Systemic sclerosis Tx
TGF b
Anti IL-2
Basilixumab
AI hepatitis type 2
Anti LKM
Paeds
T1 = Ani SM and ANA
Speckled pattern
Dermatomyositis
Nucleolar pattern
Systemic sclerosis
Homogenous pattern
drug induced SLE
Ganglioside, LM1 antibodies
Guillame Barre
Peripheral pattern
SLE
Kinetoplasts
Crithidia luciliae
Anti glutamic acid abs
Stiff man syndrome
Cause of non IgE mast cell degranulation
NSAIDs
Tx for anaphylaxis
IM adrenaline 1ml 1:1000
Tx acute urticaria
PO antihistamines
Tx for contact hypersensitivity
avoidance
tx for allergic rhinitis (hay fever)
PO antihistamines
Intranasal corticosteroids
Tx for acute angioedema
IM adrenaline 0.5ml 1:1000
WHich cytokines exert antiviral effect
IFN
whihc interleukin acts on hepatocytes to induce synthesis of acute phase proteins in response to bacterial infxn
IL-6
WHcih cells target viruses and tumours
NK cells
First cell to respond to cut?
Neutrophil
WHich part of complement is an important chemotactic agent
C3a
WHat is the pattern of ab deposition in anti GBM
smooth linear
Tx = prednisolone
gene in wiskott aldrich
WASP
Defect in SCID
IL-2 receptor
What encodes C2 C4 and factor B
MHC III
In acute rejection, what is released by CD8+
Granzyme B to kill target cells
Risk factor for chronic graft rejection
HTN
Tx of acute Ab mediated rejection
Tx of chronic cell mediated rejection
IVIG and plasmapheresis
High dose corticosteroids
3 most important HLA types
HLA DR > B > A
Which cells respond to HLA DR
Which cells respond to HLA A
CD4+
CD8+
SE of ciclosporin
gingival hypertrophy
Prevent DNA replication of:
T>B cells
B>T cells
Mycophenolate mofetil
Cyclophosphamide
How do steroids inhibit T cell function
block cytokine synthesis
SE of:
Pred
Ciclosporin
Azathioprine
Methotrexate
IVIG
HTN
HTN and reduced GFR
BM depression
Pneumonitis, pulm fibrosis and cirrhosis
Anaphylaxis