Immuno

Question 1

Low IgM, raised IgA and IgE

Answer 1

Wiskott Aldrich

Question 2

Mouse Ab targetted at CD3 to treat rejection in allograft pts

Answer 2

OKT3

Question 3

Inhibits calcineurin –> inhibits IL-2

Answer 3

Cyclosporine A

Question 4

Anti Jo1

Answer 4

Dermatomyositis

Question 5

Anti SM ab

Answer 5

AI hepatitis

Question 6

TI hypersensitivity

Answer 6

Strong CD4+ Th2 response

IL-4 and IL-12

B cells

IgE

Mast cells

Question 7

What type HS reaction is extrinsic allergic alveolitis

Answer 7

III

Farmer’s lung (mouldy hay)

Question 8

INhibits RANK L

Answer 8

Denosumab

Question 9

Berger’s disease =

Answer 9

IgA nephropathy

Question 10

Deficiency in NAPDH oxidase

Answer 10

CGD

Absent respiratory burst

Question 11

First cytokine in Type IV HS reactions

Answer 11

IL-12 from macrophages

Question 12

Tx for Bruton’s

Answer 12

IgG

Question 13

Myesthaenia gravis Tx

Answer 13

plasmapheresis

Question 14

Systemic sclerosis Tx

Answer 14

TGF b

Question 15

Anti IL-2

Answer 15

Basilixumab

Question 16

AI hepatitis type 2

Answer 16

Anti LKM

Paeds

T1 = Ani SM and ANA

Question 17

Speckled pattern

Answer 17

Dermatomyositis

Question 18

Nucleolar pattern

Answer 18

Systemic sclerosis

Question 19

Homogenous pattern

Answer 19

drug induced SLE

Question 20

Ganglioside, LM1 antibodies

Answer 20

Guillame Barre

Question 21

Peripheral pattern

Answer 21

SLE

Question 22

Kinetoplasts

Answer 22

Crithidia luciliae

Question 23

Anti glutamic acid abs

Answer 23

Stiff man syndrome

Question 24

Cause of non IgE mast cell degranulation

Answer 24

NSAIDs

Question 25

Tx for anaphylaxis

Answer 25

IM adrenaline 1ml 1:1000

Question 26

Tx acute urticaria

Answer 26

PO antihistamines

Question 27

Tx for contact hypersensitivity

Answer 27

avoidance

Question 28

tx for allergic rhinitis (hay fever)

Answer 28

PO antihistamines Intranasal corticosteroids

Question 29

Tx for acute angioedema

Answer 29

IM adrenaline 0.5ml 1:1000

Question 30

WHich cytokines exert antiviral effect

Answer 30

IFN

Question 31

whihc interleukin acts on hepatocytes to induce synthesis of acute phase proteins in response to bacterial infxn

Answer 31

IL-6

Question 32

WHcih cells target viruses and tumours

Answer 32

NK cells

Question 33

First cell to respond to cut?

Answer 33

Neutrophil

Question 34

WHich part of complement is an important chemotactic agent

Answer 34

C3a

Question 35

WHat is the pattern of ab deposition in anti GBM

Answer 35

smooth linear Tx = prednisolone

Question 36

gene in wiskott aldrich

Answer 36

WASP

Question 37

Defect in SCID

Answer 37

IL-2 receptor

Question 38

What encodes C2 C4 and factor B

Answer 38

MHC III

Question 39

In acute rejection, what is released by CD8+

Answer 39

Granzyme B to kill target cells

Question 40

Risk factor for chronic graft rejection

Answer 40

HTN

Question 41

Tx of acute Ab mediated rejection Tx of chronic cell mediated rejection

Answer 41

IVIG and plasmapheresis High dose corticosteroids

Question 42

3 most important HLA types

Answer 42

HLA DR \> B \> A

Question 43

Which cells respond to HLA DR Which cells respond to HLA A

Answer 43

CD4+ CD8+

Question 44

SE of ciclosporin

Answer 44

gingival hypertrophy

Question 45

Prevent DNA replication of: T\>B cells B\>T cells

Answer 45

Mycophenolate mofetil Cyclophosphamide

Question 46

How do steroids inhibit T cell function

Answer 46

block cytokine synthesis

Question 47

SE of: Pred Ciclosporin Azathioprine Methotrexate IVIG

Answer 47

HTN HTN and reduced GFR BM depression Pneumonitis, pulm fibrosis and cirrhosis Anaphylaxis