Hypersensitivity disorders Flashcards
Type II
HDN
AI HA (+ITP)
AI thrombocytopaenic purpura
Goodpasture’s
Pemphigus vulgaris
Graves
MG
Acute rheumatic fever
PA
Churg strauss
Wegener’s
Microscopic polyangitis
Chronic urticaria
Type III
Mixed essential cryoglobulinaemia
Serum sickness
PN
SLE
Type IV
T1DM
MS
RA
Contact dermatitis
Mantoux
Crohn’s
HDN
Maternal plasma exchange
Exchange transfusion
AI HA (+ITP = evan’s)
Steroids
AI thrombocytopaenic purpura
Steroids
IVIG
Anti D
splenectomy
Goodpasture’s
Corticosteroids and immunosuppression
Pemphigus vulgaris
Corticosteroids and immunosuppression
Graves
Carbimazole
Propylthiouracil
MG
Neostigmine
Pyridostigmine
(if serious use plasmapheresis and IVIG)
Acute rheumatic fever
Aspirin
Steroids
Penicillin
Pernicious anaemia
Dietary B12 or IM B12
Churg strauss
Prednisolone
Azathioprine
Cyclophosphamide
Wegener’s
Corticosteroids
Cyclophosphamide
Co-trimoxazole
MPA
prednisolone
cyclophosphamide or azathioprine
plasmaphoresis
Chronic urticaria
Avoid precipitants, check for thyroid disease, preventitive antihistamine, IM adrenaline for pharyngeal angioedema, 1% menthol in Aqueous cream for pruritis (also doxepin and ciclosporin)
Mixed essential cryoglobulinaemia
antigen = IgM against IgG +/- hep C antigens
tx = NSAIDs, corticosteroids and plasmaphoresis
Serum sickness
Antigen = reaction to proteins in antiserum (penicillin)
Tx = discontinuation of precipitant, steroids, antihistamines (+/- analgesia)
Polyarteritis nodosa
antigen = hep B, hep C virus antigens
tx = prednisolone and cyclophosphamide
SLE
antigen = mainly intracellular components
Tx = mainly analgesia, steroids and cyclophosphamide
T1DM
Insulin
MS
conticosteroids, IFNb
Rheumatoid arthritis (also Type III - IgM vs Fc region of IgG (RF))
analgesia, steroids, dmards
contact dermatitis
if no resolution use corticosteroids or antihistamines
crohn’s disease
antibiotics, anti-inflammatory drugs (e.g. mesalazine), TNFa antagonists (e.g. infliximab), steroids
