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Pathology (AR) > Hypersensitivity disorders > Flashcards

Hypersensitivity disorders Flashcards

1
Q

Type II

A

HDN

AI HA (+ITP)

AI thrombocytopaenic purpura

Goodpasture’s

Pemphigus vulgaris

Graves

MG

Acute rheumatic fever

PA

Churg strauss

Wegener’s

Microscopic polyangitis

Chronic urticaria

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2
Q

Type III

A

Mixed essential cryoglobulinaemia

Serum sickness

PN

SLE

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3
Q

Type IV

A

T1DM

MS

RA

Contact dermatitis

Mantoux

Crohn’s

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4
Q

HDN

A

Maternal plasma exchange

Exchange transfusion

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5
Q

AI HA (+ITP = evan’s)

A

Steroids

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6
Q

AI thrombocytopaenic purpura

A

Steroids

IVIG

Anti D

splenectomy

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7
Q

Goodpasture’s

A

Corticosteroids and immunosuppression

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8
Q

Pemphigus vulgaris

A

Corticosteroids and immunosuppression

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9
Q

Graves

A

Carbimazole

Propylthiouracil

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10
Q

MG

A

Neostigmine

Pyridostigmine

(if serious use plasmapheresis and IVIG)

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11
Q

Acute rheumatic fever

A

Aspirin

Steroids

Penicillin

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12
Q

Pernicious anaemia

A

Dietary B12 or IM B12

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13
Q

Churg strauss

A

Prednisolone

Azathioprine

Cyclophosphamide

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14
Q

Wegener’s

A

Corticosteroids

Cyclophosphamide

Co-trimoxazole

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15
Q

MPA

A

prednisolone

cyclophosphamide or azathioprine

plasmaphoresis

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16
Q

Chronic urticaria

A

Avoid precipitants, check for thyroid disease, preventitive antihistamine, IM adrenaline for pharyngeal angioedema, 1% menthol in Aqueous cream for pruritis (also doxepin and ciclosporin)

17
Q

Mixed essential cryoglobulinaemia

A

antigen = IgM against IgG +/- hep C antigens

tx = NSAIDs, corticosteroids and plasmaphoresis

18
Q

Serum sickness

A

Antigen = reaction to proteins in antiserum (penicillin)

Tx = discontinuation of precipitant, steroids, antihistamines (+/- analgesia)

19
Q

Polyarteritis nodosa

A

antigen = hep B, hep C virus antigens

tx = prednisolone and cyclophosphamide

20
Q

SLE

A

antigen = mainly intracellular components

Tx = mainly analgesia, steroids and cyclophosphamide

21
Q

T1DM

A

Insulin

22
Q

MS

A

conticosteroids, IFNb

23
Q

Rheumatoid arthritis (also Type III - IgM vs Fc region of IgG (RF))

A

analgesia, steroids, dmards

24
Q

contact dermatitis

A

if no resolution use corticosteroids or antihistamines

25
Q

crohn’s disease

A

antibiotics, anti-inflammatory drugs (e.g. mesalazine), TNFa antagonists (e.g. infliximab), steroids

Pathology (AR) (25 decks)

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