Autoantibodies

Question 1

Antiphospholipid syndrome (Hugh’s syndrome)

Answer 1

Anti-cardiolipin

Anti B2 glycoprotein

Lupus anticoagulant

Question 2

AI hepatitis

Answer 2

Anti-SM (type 1)

Anti LKM (type 2)

Anti soluble liver antigen (SLA)

Question 3

AIHA

Answer 3

Anti Rh blood group

Question 4

AI thrombocytopaenic purpura

Answer 4

Anti gpIIa/IIIb

or Ib-IX

Question 5

Churg-Strauss (eGPA)

Answer 5

p-ANCA

Question 6

Coeliac

Answer 6

IgA anti TTG and anti endomysial

Question 7

Congential heart block in infants of mothers with SLE

Answer 7

Anti-Ro

Question 8

Dermatitis herpetiformis

Answer 8

Anti endomysial

Seen in coeliac

Question 9

Dermatomyositis

Answer 9

Anti Jo1 (t-RNA synthetase)

Question 10

Diffuse systemic scleroderma

Answer 10

Anti topoisomerase/Scl 70, RNA Pol I, II, III, Fibrillarin

Question 11

Goodpastures

Answer 11

Anti GBM

Question 12

Graves

Answer 12

Anti TSH receptor

Question 13

Hashimoto’s

Answer 13

Anti thyroglobulin and thyroperoxidase

Question 14

Limited systemic scleroderma

Answer 14

Anti centromere

Question 15

Microscopic polyangitis

Answer 15

p-ANCA

Question 16

Mixed connective tissue disease

Answer 16

Anti U1RNP (speckled pattern)

Question 17

MG

Answer 17

Anti ACh receptor

Question 18

Pernicious anaemia

Answer 18

Anti parietal cell (90%)

Anti intrinsic factor (50%)

Question 19

Polymyositis

Answer 19

Anti Jo1 (t-RNA synthetase)

Question 20

PBC

Answer 20

Anti mitochondrial

Question 21

RA

Answer 21

Anti CCP

RF

Question 22

Sjogren’s

Answer 22

Anti Ro

Anti La (speckled pattern)

RF

Question 23

SLE

Answer 23

Anti dsDNA and histones
Anti Ro and La
Anti Sm
U1RNP (speckled)

Question 24

T1DM

Answer 24

Anti glutamate decarboxylase and pancreatic b cells

Question 25

Wegener’s

Answer 25

c-ANCA

anti proteinase 3