ChemPath

Question 1

What tests for all drugs of abuse

Answer 1

Immunoassay

Question 2

What sample required for gas chromatography

Answer 2

Blood sample

Question 3

Investigating benzos and antipsychotics

Answer 3

Liquid chromatography

Question 4

Analysing stool and liver and urine

Answer 4

thin layer chromatography

Question 5

Hormone raised in CAH serum

Answer 5

17 hydroxyprogesterone

Question 6

Hormone raised in CAH urine

Answer 6

Pregnanetriol

Question 7

Good marker of reinfarction (heart)

Answer 7

CKMB - rises and falls v quickly

Question 8

Hormone change in chronic late pancreatitis

Answer 8

decreased amylase

Question 9

thyroid cancer plus calcitonin =

Answer 9

medullary

Question 10

iatrogenic hypothyroidism can be caused by which drug

Answer 10

Metformin

Question 11

No MMR vaccine thyroid problem

Answer 11

Giant cell thyroiditis

Question 12

Stridor + multinodular thyroid =

Answer 12

simple colloid goitre

Question 13

Stiffness following exercise =

Answer 13

McArdle’s

mycophosphorylase def

Question 14

Deficiency in scid

Answer 14

adenosine deaminase

Question 15

Tx for AIA attack

Answer 15

Haem arginate

Question 16

Anti inflam drug CI in pts with porphyria

Answer 16

diclofenac

Question 17

Drug can result in chronic porphyria

Answer 17

Alcohol

Question 18

Mx acute anxiety

Answer 18

Diazepam

Question 19

Abx CI in porphyria

Answer 19

co-trimoxazole

Question 20

Neurotoxic breakdown broduct of heme which causes neurovisceral damage =

Answer 20

5 aminolevulinic acid

5 ALA

Question 21

Products of heme breakdown which cause photosenstivity

Answer 21

activated porphyrins and oxygen free radicals

Question 22

Major antagonist of serene proteases at site of injury

Answer 22

alpha1 antitrypsin

Question 23

substance formed in insulin independent cells

Answer 23

sorbitol

Question 24

episodic abdo pain + recurrent pancreatitis + milky plasma + chylomicrons in plasma following fasting =

Answer 24

lipoprotein lipase def

present on capillaries of adipose and skeletal muscle and removes TGs from lipoproteins

Question 25

Main carrier of TGs

Answer 25

chylomicrons

Question 26

haemoglobinuria is a sign of?

Answer 26

INTRAVASCULAR haemolysis

Question 27

disease more common in quebec?

Answer 27

T1 tyrosinaemia

Question 28

Inborn error with dysmorphic signs

Answer 28

Jaundiced?

Yes:

Peroxismal disorders of glycosylation

No:

congenital disorders of glycosylation

Question 29

Self mutilation, delayed motor development, abundant orange coloured ‘sand’ (uric acid) crystals in nappies

Answer 29

Lesch Nyan

Question 30

Renal stones

Answer 30

Calcium mixed (45%) - Radioopaque

Calcium oxalate (35%) - Radioopaque

Calcium phosphate (1%) - Radioopaque

Triple phosphate “struvite” (10%) - Radioopaque - staghorn

Uric acid (5%) - Radiolucent

Cysteine (1-2%) - Radiolucent

Others e.g. xanthine (rare)