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Pathology (AR) > ChemPath > Flashcards

ChemPath Flashcards

1
Q

What tests for all drugs of abuse

A

Immunoassay

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2
Q

What sample required for gas chromatography

A

Blood sample

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3
Q

Investigating benzos and antipsychotics

A

Liquid chromatography

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4
Q

Analysing stool and liver and urine

A

thin layer chromatography

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5
Q

Hormone raised in CAH serum

A

17 hydroxyprogesterone

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6
Q

Hormone raised in CAH urine

A

Pregnanetriol

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7
Q

Good marker of reinfarction (heart)

A

CKMB - rises and falls v quickly

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8
Q

Hormone change in chronic late pancreatitis

A

decreased amylase

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9
Q

thyroid cancer plus calcitonin =

A

medullary

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10
Q

iatrogenic hypothyroidism can be caused by which drug

A

Metformin

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11
Q

No MMR vaccine thyroid problem

A

Giant cell thyroiditis

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12
Q

Stridor + multinodular thyroid =

A

simple colloid goitre

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13
Q

Stiffness following exercise =

A

McArdle’s

mycophosphorylase def

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14
Q

Deficiency in scid

A

adenosine deaminase

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15
Q

Tx for AIA attack

A

Haem arginate

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16
Q

Anti inflam drug CI in pts with porphyria

A

diclofenac

17
Q

Drug can result in chronic porphyria

A

Alcohol

18
Q

Mx acute anxiety

A

Diazepam

19
Q

Abx CI in porphyria

A

co-trimoxazole

20
Q

Neurotoxic breakdown broduct of heme which causes neurovisceral damage =

A

5 aminolevulinic acid

5 ALA

21
Q

Products of heme breakdown which cause photosenstivity

A

activated porphyrins and oxygen free radicals

22
Q

Major antagonist of serene proteases at site of injury

A

alpha1 antitrypsin

23
Q

substance formed in insulin independent cells

A

sorbitol

24
Q

episodic abdo pain + recurrent pancreatitis + milky plasma + chylomicrons in plasma following fasting =

A

lipoprotein lipase def

present on capillaries of adipose and skeletal muscle and removes TGs from lipoproteins

25
Q

Main carrier of TGs

A

chylomicrons

26
Q

haemoglobinuria is a sign of?

A

INTRAVASCULAR haemolysis

27
Q

disease more common in quebec?

A

T1 tyrosinaemia

28
Q

Inborn error with dysmorphic signs

A

Jaundiced?

Yes:

Peroxismal disorders of glycosylation

No:

congenital disorders of glycosylation

29
Q

Self mutilation, delayed motor development, abundant orange coloured ‘sand’ (uric acid) crystals in nappies

A

Lesch Nyan

30
Q

Renal stones

A

Calcium mixed (45%) - Radioopaque

Calcium oxalate (35%) - Radioopaque

Calcium phosphate (1%) - Radioopaque

Triple phosphate “struvite” (10%) - Radioopaque - staghorn

Uric acid (5%) - Radiolucent

Cysteine (1-2%) - Radiolucent

Others e.g. xanthine (rare)

Pathology (AR) (25 decks)

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