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PGY-4 Board Prep > Immunity/Allergy > Flashcards

Immunity/Allergy Flashcards

1
Q

Type 1 Drug Reactions

A

IgE-mediated, tend to happen immediately (within 1 hr)

can have delayed response , prior exposure

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2
Q

Type 2 Drug Reactions

A

Ab mediated, IgG or IgM binds receptor –> complement activation

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3
Q

Examples of Type 2 Exposures

A

AIHA
Goodpastures
Myasthenia

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4
Q

SJS versus TEN (%)

A

SJS <10% BSA

TEN >30% BSA

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5
Q

Type 3 Drug Reaction

A

Immune Complex Mediated

Vasculitis

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6
Q

Examples of Type 3 Exposures

A

Serum Sickness, Arthrus Rxn, Autoimmune Diseases, Tetanus/Diphtheria

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7
Q

Type 4 Drug Reaction

A

T cell / Cell mediated Hypersensitivity

24-72 hours

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8
Q

Examples of Type 4 Drug Reactions

A

Morbilliform rash/drug reaction
fixed drug reaction
DRESS
SJS/TEN

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9
Q

Innate Immune System

A

nonspecific, rapid

complement, macrophages, NK cells

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10
Q

Adaptive Immune System

A

Specific, Memory

Divides into Humoral and Cell-Meditaed

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11
Q

Humoral Adaptive Immune System

A

B cells, Plasma Cells, IgS

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12
Q

Cell Mediated Adaptive Immune System

A

T cells

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13
Q

CD4 vs CD8 cells

A

CD4 - extracellular

CD8 - intracellular, cytotoxic

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14
Q

CD4 Th1 cells

A

induce CD8+

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15
Q

CD4 th2 Cells

A

Induce B cells, Abs

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16
Q

X Linked gammaglobulinemia

A

males w/ absent and minimal tonsils
low Igs of all types
recurrent bacterial infections, giardia, enterovirus

17
Q

CVID

A

defieincy of at least 2 subclasses + poor response to vaccines
recurrent sinus and pulmonary infections

18
Q

CVID - associated illnesses/things

A

sarcoid like disease
autoimmune illnesses
malabsporption/PLE

19
Q

Selective IgA Deficiency

A

asymptomatic to sinopulmonary infections

increased risk of AI diseases - hashiomoto, celiac dx

20
Q

Specific Antibody Deficiency

A

normal Igs but poor response to vaccines

PGY-4 Board Prep (18 decks)

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