Immune System Flashcards
granular leukocytes an dphagocytic cells
attack infectious agents
natural killer cells attack
virus infected and tumor cells
cytokines
variety of types from a variety of cells that enhance immune response nonspecifically
complement system
plasma proteins that can lyse microorganisms and stimulate phagocytic cells
5 things of specific immunity
specificity diversity memory self limitation tolerance
where do immunoglobulins come from
b cells
where do lymphokines come from
t cells
MHC1
on all nucleated body cells
MHC2
on antigen presenting cells
MHC2 use
antigen presenting cells put MHC2 onto partially digested foreign proteins so T cells can recognize them and neutralize them
types of antigen presenting cells
macorphages
langerhan cells
thyme epithelial reticular cells
dendritic cells
helper t cell
recognizes and binds antigen-MHCII complexes on antigen presenting cells
help to stimulate b cell differntiation
cytotoxic t cells
recognize abnormal MHC1 on transformed cells and release perforins to cause membrane damage or activate apoptosis genes
suppressor t cells
decrease b and t cell activity
memory t cells
specific receptors for a specific antigen
b cell receptor components
immunoglobulins complexed with IGalpha and IGbeta on b cell surface
b cell activation
antigen binds BCR, endocytosed, complexed with MHCII
T helper binds antigen and releases lymphokines with activate to plasma cells
IgM
first immunoglobulin produced by b cells
activates complement system
IgG
most abdunent
activates complement system
only one that can cross the placental barrier
IgE
attaches to mast cells and basophils
mediates release of histamine and heparin in allergy responses
IgA
from plasma cells in organ mucosa
IgD
on surface of B cell and acts as a B cell receptor
4 types of vaccination
killed/attenuated
subunit/recombinant- certain parts removed and put into a less dangerous host
toxoid- inactive toxic component
conjugate- things linked to the organism so the immune cells will access it easier
