Blood Flashcards
what is blood stained with
romanovsky or wright wtain
plasma components
proteins- albumen, immunoglobulins, coagulation oproteins, lipoproteins, carrier proteins
mineral salts
water
what is serum
plasma without the coagulation factors
spectrin defects lead to ___ in RBC
eliliptocytosis
spherocytosis
rh factor
expression of cell surface proteins that are not A or B (C, D, E most common)
hemolytic disease of newborn
rh negative mother is sensitized from previous rh positive birth and antibodies attack RBC of second rh positive fetus
things affecting RBC count
hypoxia
hemorrhage
hormones
hemolytic anemia
early RBC destruction
sickle cell anemia
genetic mutation in hemoglobin
polycythemia
increased RBC
azurophilic granules
primary lysosomes present in all leukocytes
agranular leukocytes
lymphocytes
monocytes
granular leukocytes
basophils
neutrophils
eosinophils
neutrophils
3+ segments to nucleus
eosinophils
bilobed nucleus with coarse granules
specific granules in a neutrophil
collagenase
elastase
alkaline phosphatase
bacteriocidal enzymes
specific granules in an eosinophil
acidophilic–
bacteriocidal
acid phosphatase
major basic protein
eosinophils are most active in
allergic reactions and parasitic infections
role of neutrophils
first line of innate defense
basophils
bilobed nucleus hidden by granules
specific granules of basophil
basophilic–
heparin
histamine
eosinophilic chemotactic factor
basophil function
similar to mast cell– hypersensitivity reaction (bronchiole constriction and anaphylaxis)
monoocytes
ruffled boarder
indented nucleus
thin rim of cytoplasm
monocytes differentitate into
macorphages
microglia
osteoclasts
kupffer cells
lymphocytes
round or kidney shaped nucleus with a thin rim of cytoplasm
larger than RBC
types of lymphocytes
B cells
T cells
natural killer cells
b cells mature in ____ to become ____
connective tissue/lymphoid tissue
plasma cells
t cells mature in the
thymus
cell platelets come from
megakaryocytes
controller of platelet formation
thrombopoeitin
structure of platelet
outer coat of glycoproteins
marginal zone of microtubules
peripheral zone (hyalomere) of actin and myosin
inner zone (granulomere) of granules
platelet specific granules
lysozomal enzymes
stored serotonin taken from plasma
coagulation proteins of platelets
von Hillebrand factor- factor VIII
glycoprotein 1b- factor IX
hemophilia type A
defective or deficient factor VIII
hemophila type b
defective or deficient factor IX
thrombocytopenia
decreased platelets
thrombocytosis
increased platelets
main steps in clot formation
platelet plug secondar aggregation coagulation cascade clot retraction clot removal