Hematopoeisis Flashcards
early embryo/fetus blood cell formation occurs in
yolk sac mesoderm- liver and spleen
bone ossification begins at
2 months genstation
marrow is primary blood forming organ at
7 months gestation
red bone marrow
active
flat bones and ends of long bones
yellow marrow
inactive, mainly adipose
capillary type in marrow
sinusoidal
blood flow path in bones
nutrient artery central longitudinal a radial a cortical capillaries medullar sinus/sinusoidal cap central sinus emissary vein
blood cells come from
pluripotent stem cells
2 lineages from pluripotent stem cell
lymphoid–> lymphocytes
myeloid–> all other blood cells
colony forming units of lymphoid lineage
b cell
T cell
CFU of myeloid
erythrocyte
megakakryocyte
granulocyte/monocyte
erythropoeisis
RBC production
reticulocyte
immature RBC that still has some organelles
reticulocytosis
increased number of reticulocytes in circulation gblood
factors influencing RBC production
erythropoeitin
B12 and intrinsic factor
folate
iron
granulopoeisis
production of granular leukocytes
path of neutrophils as they mature
bone marrow
-medullary formation compartment- mitosis and maturation
-medullary storage compartment- released on demand
blood
-circulation 6-7 hours
-marginating compartment- sequestered in capillaries
CT- last up to 4 days
neutrophilia
high numbers of neutrophils in blood
causes of neutrophili
epinephrine
glucocorticoids
infection
cells that come from monocytes
macrophage microglia cupful cells osteoclasts langerhan cells
t cells mature in the
thymus
b cells mature in the
bone marrow or lymphoid tissue (GALT specitifally)
magakaryocytes form
platelets
____ cancers commonly metastasize to bone
breast prostate lung kidney thyroid
chronic leukemia
neoplastic transformation of a more mature cell type
less aggressive because all the other cell types are normal
acute leukemia
proliferation/transformation of immature cells
more aggressive
