Hematopoeisis

Question 1

early embryo/fetus blood cell formation occurs in

Answer 1

yolk sac mesoderm- liver and spleen

Question 2

bone ossification begins at

Answer 2

2 months genstation

Question 3

marrow is primary blood forming organ at

Answer 3

7 months gestation

Question 4

red bone marrow

Answer 4

active

flat bones and ends of long bones

Question 5

yellow marrow

Answer 5

inactive, mainly adipose

Question 6

capillary type in marrow

Answer 6

sinusoidal

Question 7

blood flow path in bones

Answer 7

nutrient artery
central longitudinal a
radial a
cortical capillaries
medullar sinus/sinusoidal cap
central sinus
emissary vein

Question 8

blood cells come from

Answer 8

pluripotent stem cells

Question 9

2 lineages from pluripotent stem cell

Answer 9

lymphoid–> lymphocytes

myeloid–> all other blood cells

Question 10

colony forming units of lymphoid lineage

Answer 10

b cell

T cell

Question 11

CFU of myeloid

Answer 11

erythrocyte
megakakryocyte
granulocyte/monocyte

Question 12

erythropoeisis

Answer 12

RBC production

Question 13

reticulocyte

Answer 13

immature RBC that still has some organelles

Question 14

reticulocytosis

Answer 14

increased number of reticulocytes in circulation gblood

Question 15

factors influencing RBC production

Answer 15

erythropoeitin
B12 and intrinsic factor
folate
iron

Question 16

granulopoeisis

Answer 16

production of granular leukocytes

Question 17

path of neutrophils as they mature

Answer 17

bone marrow
-medullary formation compartment- mitosis and maturation
-medullary storage compartment- released on demand
blood
-circulation 6-7 hours
-marginating compartment- sequestered in capillaries
CT- last up to 4 days

Question 18

neutrophilia

Answer 18

high numbers of neutrophils in blood

Question 19

causes of neutrophili

Answer 19

epinephrine
glucocorticoids
infection

Question 20

cells that come from monocytes

Answer 20

macrophage
microglia
cupful cells
osteoclasts
langerhan cells

Question 21

t cells mature in the

Answer 21

thymus

Question 22

b cells mature in the

Answer 22

bone marrow or lymphoid tissue (GALT specitifally)

Question 23

magakaryocytes form

Answer 23

platelets

Question 24

____ cancers commonly metastasize to bone

Answer 24

breast
prostate
lung
kidney
thyroid

Question 25

chronic leukemia

Answer 25

neoplastic transformation of a more mature cell type

less aggressive because all the other cell types are normal

Question 26

acute leukemia

Answer 26

proliferation/transformation of immature cells

more aggressive