Immune Evasion Flashcards
1
Q
Microbial subversion of host innate immunity (5)
A
Subversion of innate immune responses
- evasion of antimicrobial peptides
- impairment of tracheal clearance
- adhesion and penetration of epithelial barriers
- evasion of phagocytosis
- evasion of compliment killing
2
Q
Microbial subversion of host adaptive immunity (7)
A
Microbial subversion of host adaptive immunity
- antigenic variation
- change clothes
- apoptosis or lysis of lymphocytes
- take em out
- inhibition of lymphocyte proliferation
- prevent backup
- superantigens
- overreactive immune response
- effects on cytokine expression
- shoot the messenger
- subversion of T regulatory cells
- hide from cops
- degradation of immunoglobulins
- destroy receptors
3
Q
Evasion of Anti-microbal Peptides
A
method of subversion of innate immune response
Evasion of Anti-microbal Peptides
= family of peptides with bactericidal activity
- staphylococus aureus
- bind definsins forming inactive complexes
- bordetella brochieptica
- reduce definsin reproduction
4
Q
Impairment of tracheal clearance
A
method of subversion of innate immune response
Impairment of tracheal clearance
- pseudomonas aeruginosa
- toxins slow/stop ciliary beating
- bordetella pertussis
- impairs ability to clear mucus
- mycoplasma spp.
- induce derangment of cilial function
5
Q
evade phagocytosis
A
method of subversion of innate immune response
exade phagocytosis
1.) avoid being phagocytized
- create a diversion
- play hard to get (capsule)
- paralysis (inactivate C5a)
2.) after being phagocytized
- membrane lysis
- resist/inhibit lysosomal enzymes
- inhibit oxidative killing
- escape into cytoplasm
6
Q
Evasion of complement killing
A
method of subversion of innate immune response
evasion of complement killing
- activate masking substances
- apply appropriate inhibitors of activation to surface
- cover up target of membrane attack complex
- inactivate complement chemotaxin C5a
- activate surface of plasminogen to plasmin and cleave C3b
