immune/blood term, inflammation Flashcards
anoxia
absence of oxygen
hypoxia
deficiency of oxygen
septicemia
pathogens or toxins in the blood, can include bacteremia
bacteremia
bacteria in blood
chemotaxis
movement of WBCs along concentration gradient of tissue damage byproducts
pavementing/margination
WBCs lining the damaged vessels
Diapedesis AKA leukocyte extravasation
neutrophils and monocytes squeeze through the wallas of blood vessels towards site of damaged tissue or infection
clot
fibrinogen into fibrin via thromboplastin
thrombus
platelet deposition
embolus
foreign body in the blood travels
exudate
fluid and high protein
transudate
fluid and low protein
1st stage of inflammation; Injury
tissue is damaged
2nd stage of inflammation; vasoconstriction
sympathetic reaction. wound does not spew blood unless artery was damaged
3rd stage inflammation; vasodilation
bring more blood to injured site. histamine and bradykinin dilate vessels
4th stage inflammation; swelling/edema
cells move into damaged area. chemotaxis>diapedesis /leukocyte extravasation
5th stage inflammation; healing
mast cells make heparin and serotonin. serotonin: for wound healing, stimulates the myofibroblasts which cause constriction and form type 3 collagen for early wound healing. fibrin forms the scar
basophils
become mast cells, make histamine, bradykinin, serotonin, heparin
b-lymphocytes
transforms into plasma cells >make antibodies
granuloctyes
BEN: basophils, eosinophils, neutrophils
agranulocytes
lymphocytes and monocytes
macrophage
monocyte at tissue level. kupffer-liver, dust-lung, microglia-brain. langerhan-skin
NK cells
MEN. Monocytes, eosinophils, neutrophils
t-helper cells
CD4 cells=activated b cells
t-killer cells
CD8 cells=cytotoxic cells. destroys cancer. kills foreign agents, eg transplant rejections
t suppressor cells
t-regulatory cells. decrease immune system. slows antibody production
Neutrophils
60%. increase in acute bacterial infections and acute inflammation
lymphocytes
30%. increase in viral condtions and chronic inflammation
monocytes
5-8%. chronic conditions. changes into phagocytes at tissue level
eosinophils
2-4%. increase in parasites and allergies
basophils
0-0.5%. like mast cells. produce heparin and histamine. increase conditions that cause histamine release