IM1- Pharm 2 quiz Flashcards
What is pharmacokinetics?
How a drug moves through the body
What are some questions that should come to mind when thinking in terms of pharmocokinetics?
- How does the drug get into the body and where does it go?
- What does the body do to/with the drug?
- How does the body get rid of the drug?
What is the process of a drug through the body?
- absorption
- distribution
- metabolism
- excretion
True or false: different drugs are metabolized by different organs?
True
True or false: the majority of drugs are metabolized by the liver
True
Where are the majority of drugs excreted?
Kidneys
What is absorption?
The movement of a drug from its site of administration into the blood
In pharmacology rate is determines what?
How soon a drugs effects will take place
In pharmacology amount determines what?
how intense the drugs effects will be
Name 6 factors that affect the process of absorption.
- Rate of dissolution
- surface area
- blood flow
- Lipid solubility
- pH partitioning
- Route of administration
True or false: With rate of dissolution the quicker a drug dissolves the slower the effect will be?
False
True or false: With surface area the larger the surface area the quicker the drug is absorbed
True
True or false: Our body prefer drugs that are lipid soluble because it is easier for them to enter our blood stream.
true
What are the two major groups in routes of administration?
Enteral (gastrointestinal GI tract)
Parenteral (outside of the GI tract)
Is oral meds considered enteral or parenteral?
enteral
Is IV, subQ and IM considered enteral or parenteral?
Parenteral
What are the advantages to PO meds?
- Safer than injections
- ideal for self-administration
- easy, convenient and inexpensive
What are the disadvantages to PO meds?
1.Can cause GI irritation
2. Requires cooperative patient
3. Inactivation
4. Varibility
What are some barriers to absorption with PO meds?
- Epithelial lining of GI tract
- capillary wall
What is the absorption pattern for PO meds?
Slow and variable
True or false: no one patient absorbs the drugs the same
true
What are some advantages of IV drugs? List 4
- Rapid onset
- Control
- permits use of lg fluid volumes
- permits use of irritant drugs (chemo drugs)
What are some disadvantages of IV drugs? List 4
- High cost, difficulty, inconvenience
- irreversibility
- infection
4.high risk
What are the barriers of absorption for IV drugs?
None goes directly into blood stream
What is the absorption pattern for IV drugs?
Instantaneous and complete